Chronic sinusitis and atopy: A cross-sectional study

G. Leo, E. Piacentini, C. Incorvaia, D. Consonni, F. Frati

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The role of allergic sensitization in chronic sinusitis in childhood is currently unclear, as contrasting results were reported in the studies thus far available. Objective: We evaluated by a cross-sectional study the prevalence of sensitization to common inhalant allergens in children with chronic sinusitis. Methods: Among 2200 children referring to our Paediatric out-patient Unit for evaluation of chronic respiratory symptoms, subjects satisfying at least two of major criteria for the definition of chronic sinusitis were recruited, and underwent to allergen sensitization workup by skin prick test (SPT) with common inhalant allergens and total IgE determination. Participants were stratified according to age inferior to three years (Group 1), age between three and six years (Group 2), and age above six years (Group 3) for the purpose of evaluation. Results: In all, 351 children (217 boys, 134 girls, mean age 5.23 ? 2.11 years, range 4-15 years) were available for evaluation and were stratified (27 in Group 1, 261 in Group 2 and 63 in Group 3). Prevalence of both sensitization to at least one inhalant allergen by SPT and of high total IgE was 29.9%. Prevalence of SPT sensitization was significantly different across age groups, with a value of 7.4% in Group 1, 31.4% in Group 2 and 33.3% in Group 3 (p = 0.028), but after adjusting for age, sinusitis and aeroallergen sensitization did not correlate significantly. The difference across groups for high total IgE did not reach statistical significance, with 22.7%, 30.1% and 32.1% for each group respectively. Conclusions: The prevalence of sensitization to aeroallergens in children with chronic sinusitis is comparable to that of the general paediatric population, as assessed in the Italian arm of the ISAAC study. This does not account for routine investigation for allergy in children diagnosed with such disease.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalEuropean Annals of Allergy and Clinical Immunology
Volume38
Issue number10
Publication statusPublished - Dec 2006

Fingerprint

Sinusitis
Cross-Sectional Studies
Allergens
Skin Tests
Immunoglobulin E
Age Groups
Pediatrics
Hypersensitivity
Outpatients
Population

Keywords

  • Allergic sensitization
  • Chronic sinusitis
  • Skin prick test
  • Total IgE

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Leo, G., Piacentini, E., Incorvaia, C., Consonni, D., & Frati, F. (2006). Chronic sinusitis and atopy: A cross-sectional study. European Annals of Allergy and Clinical Immunology, 38(10), 361-363.

Chronic sinusitis and atopy : A cross-sectional study. / Leo, G.; Piacentini, E.; Incorvaia, C.; Consonni, D.; Frati, F.

In: European Annals of Allergy and Clinical Immunology, Vol. 38, No. 10, 12.2006, p. 361-363.

Research output: Contribution to journalArticle

Leo, G, Piacentini, E, Incorvaia, C, Consonni, D & Frati, F 2006, 'Chronic sinusitis and atopy: A cross-sectional study', European Annals of Allergy and Clinical Immunology, vol. 38, no. 10, pp. 361-363.
Leo, G. ; Piacentini, E. ; Incorvaia, C. ; Consonni, D. ; Frati, F. / Chronic sinusitis and atopy : A cross-sectional study. In: European Annals of Allergy and Clinical Immunology. 2006 ; Vol. 38, No. 10. pp. 361-363.
@article{a72dd7c6b0464210b6a34f0d5971cd5e,
title = "Chronic sinusitis and atopy: A cross-sectional study",
abstract = "Background: The role of allergic sensitization in chronic sinusitis in childhood is currently unclear, as contrasting results were reported in the studies thus far available. Objective: We evaluated by a cross-sectional study the prevalence of sensitization to common inhalant allergens in children with chronic sinusitis. Methods: Among 2200 children referring to our Paediatric out-patient Unit for evaluation of chronic respiratory symptoms, subjects satisfying at least two of major criteria for the definition of chronic sinusitis were recruited, and underwent to allergen sensitization workup by skin prick test (SPT) with common inhalant allergens and total IgE determination. Participants were stratified according to age inferior to three years (Group 1), age between three and six years (Group 2), and age above six years (Group 3) for the purpose of evaluation. Results: In all, 351 children (217 boys, 134 girls, mean age 5.23 ? 2.11 years, range 4-15 years) were available for evaluation and were stratified (27 in Group 1, 261 in Group 2 and 63 in Group 3). Prevalence of both sensitization to at least one inhalant allergen by SPT and of high total IgE was 29.9{\%}. Prevalence of SPT sensitization was significantly different across age groups, with a value of 7.4{\%} in Group 1, 31.4{\%} in Group 2 and 33.3{\%} in Group 3 (p = 0.028), but after adjusting for age, sinusitis and aeroallergen sensitization did not correlate significantly. The difference across groups for high total IgE did not reach statistical significance, with 22.7{\%}, 30.1{\%} and 32.1{\%} for each group respectively. Conclusions: The prevalence of sensitization to aeroallergens in children with chronic sinusitis is comparable to that of the general paediatric population, as assessed in the Italian arm of the ISAAC study. This does not account for routine investigation for allergy in children diagnosed with such disease.",
keywords = "Allergic sensitization, Chronic sinusitis, Skin prick test, Total IgE",
author = "G. Leo and E. Piacentini and C. Incorvaia and D. Consonni and F. Frati",
year = "2006",
month = "12",
language = "English",
volume = "38",
pages = "361--363",
journal = "Allergie et Immunologie",
issn = "0397-9148",
publisher = "Mattioli 1885 S.p.A.",
number = "10",

}

TY - JOUR

T1 - Chronic sinusitis and atopy

T2 - A cross-sectional study

AU - Leo, G.

AU - Piacentini, E.

AU - Incorvaia, C.

AU - Consonni, D.

AU - Frati, F.

PY - 2006/12

Y1 - 2006/12

N2 - Background: The role of allergic sensitization in chronic sinusitis in childhood is currently unclear, as contrasting results were reported in the studies thus far available. Objective: We evaluated by a cross-sectional study the prevalence of sensitization to common inhalant allergens in children with chronic sinusitis. Methods: Among 2200 children referring to our Paediatric out-patient Unit for evaluation of chronic respiratory symptoms, subjects satisfying at least two of major criteria for the definition of chronic sinusitis were recruited, and underwent to allergen sensitization workup by skin prick test (SPT) with common inhalant allergens and total IgE determination. Participants were stratified according to age inferior to three years (Group 1), age between three and six years (Group 2), and age above six years (Group 3) for the purpose of evaluation. Results: In all, 351 children (217 boys, 134 girls, mean age 5.23 ? 2.11 years, range 4-15 years) were available for evaluation and were stratified (27 in Group 1, 261 in Group 2 and 63 in Group 3). Prevalence of both sensitization to at least one inhalant allergen by SPT and of high total IgE was 29.9%. Prevalence of SPT sensitization was significantly different across age groups, with a value of 7.4% in Group 1, 31.4% in Group 2 and 33.3% in Group 3 (p = 0.028), but after adjusting for age, sinusitis and aeroallergen sensitization did not correlate significantly. The difference across groups for high total IgE did not reach statistical significance, with 22.7%, 30.1% and 32.1% for each group respectively. Conclusions: The prevalence of sensitization to aeroallergens in children with chronic sinusitis is comparable to that of the general paediatric population, as assessed in the Italian arm of the ISAAC study. This does not account for routine investigation for allergy in children diagnosed with such disease.

AB - Background: The role of allergic sensitization in chronic sinusitis in childhood is currently unclear, as contrasting results were reported in the studies thus far available. Objective: We evaluated by a cross-sectional study the prevalence of sensitization to common inhalant allergens in children with chronic sinusitis. Methods: Among 2200 children referring to our Paediatric out-patient Unit for evaluation of chronic respiratory symptoms, subjects satisfying at least two of major criteria for the definition of chronic sinusitis were recruited, and underwent to allergen sensitization workup by skin prick test (SPT) with common inhalant allergens and total IgE determination. Participants were stratified according to age inferior to three years (Group 1), age between three and six years (Group 2), and age above six years (Group 3) for the purpose of evaluation. Results: In all, 351 children (217 boys, 134 girls, mean age 5.23 ? 2.11 years, range 4-15 years) were available for evaluation and were stratified (27 in Group 1, 261 in Group 2 and 63 in Group 3). Prevalence of both sensitization to at least one inhalant allergen by SPT and of high total IgE was 29.9%. Prevalence of SPT sensitization was significantly different across age groups, with a value of 7.4% in Group 1, 31.4% in Group 2 and 33.3% in Group 3 (p = 0.028), but after adjusting for age, sinusitis and aeroallergen sensitization did not correlate significantly. The difference across groups for high total IgE did not reach statistical significance, with 22.7%, 30.1% and 32.1% for each group respectively. Conclusions: The prevalence of sensitization to aeroallergens in children with chronic sinusitis is comparable to that of the general paediatric population, as assessed in the Italian arm of the ISAAC study. This does not account for routine investigation for allergy in children diagnosed with such disease.

KW - Allergic sensitization

KW - Chronic sinusitis

KW - Skin prick test

KW - Total IgE

UR - http://www.scopus.com/inward/record.url?scp=33846444352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846444352&partnerID=8YFLogxK

M3 - Article

C2 - 17274521

AN - SCOPUS:33846444352

VL - 38

SP - 361

EP - 363

JO - Allergie et Immunologie

JF - Allergie et Immunologie

SN - 0397-9148

IS - 10

ER -