Chronic stress induces strain-dependent sensitization to the behavioral effects of amphetamine in the mouse

Aldo Badiani, Simona Cabib, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Following 10 days of daily restraint stress, sensitization developed to the stimulatory effect of amphetamine on locomotion in DBA/2 but not in C57BL/6 mice tested 24 h after the last stressful experience regardless of their being naive or habituated to the test cages. Saline-injected C57BL/6 mice, however, showed an increase of locomotion 24 h after chronic stress treatment. Chronically stressed mice of the two strains did not exhibit any alteration of dopamine and metabolites (3-4-dihydroxyphenylacetic acid, homovanillic acid, and 3-methoxytyramine) levels in the frontal cortex, caudatus putamen, or nucleus accumbens septi, thus ruling out that stress-induced alteration of basal dopamine metabolism affected the behavioral response to amphetamine challenging in DBA/2 mice. Ten daily amphetamine injections (5 mg/kg) did not significantly modify the behavioral response to amphetamine in either strain of mice tested 24 h after the end of the chronic treatment and did not increase locomotion in saline-injected C57BL/6 mice. Finally, chronically stressed hybrids B6D2F1 did not show sensitization to the locomotor effects of amphetamine, suggesting a dominant mode of inheritance in the response to chronic stress of the C57BL/6 strain.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number1
DOIs
Publication statusPublished - 1992

Fingerprint

Amphetamine
Locomotion
Inbred C57BL Mouse
Dopamine
Basal Metabolism
Homovanillic Acid
Inbred DBA Mouse
Caudate Nucleus
Putamen
Nucleus Accumbens
Frontal Lobe
Metabolites
Metabolism
Injections
Acids
Therapeutics

Keywords

  • Dopamine autoreceptors
  • Dopamine metabolism
  • Genotype
  • Locomotion

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Chronic stress induces strain-dependent sensitization to the behavioral effects of amphetamine in the mouse. / Badiani, Aldo; Cabib, Simona; Puglisi-Allegra, Stefano.

In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 1, 1992, p. 53-60.

Research output: Contribution to journalArticle

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