Chronic stress reduces the analgesic but not the stimulant effect of morphine in mice

Stefano Puglisi-Allegra, Simona Cabib, Alberto Oliverio

Research output: Contribution to journalArticlepeer-review

Abstract

After 10 daily 2-h sessions of immobilization stress, C57BL/6 mice show a reduced response to the analgesic effects of morphine. Chronic stress does not modify the stimulant effect of morphine on locomotor activity. These results are discussed in terms of the effects of stress on different endorphinergic systems.

Original languageEnglish
Pages (from-to)357-358
Number of pages2
JournalBrain Research
Volume380
Issue number2
DOIs
Publication statusPublished - Aug 20 1986

Keywords

  • analgesia
  • chronic stress
  • locomotor activity
  • mice
  • opioid tolerance

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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