Abstract
We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 363-367 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Haematology |
| Volume | 33 |
| Issue number | 4 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Hematology
Cite this
Chronic T lymphocytic leukaemia : Antigenic, morphological and functional properties of the neoplastic lymphocytes. / de Paoli, P.; Nimis, R.; Molaro, G. L.; Battistin, S.; Reitano, M.; Castiglia, C.; de Filippo, I.; Santini, G.
In: Scandinavian Journal of Haematology, Vol. 33, No. 4, 1984, p. 363-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic T lymphocytic leukaemia
T2 - Antigenic, morphological and functional properties of the neoplastic lymphocytes
AU - de Paoli, P.
AU - Nimis, R.
AU - Molaro, G. L.
AU - Battistin, S.
AU - Reitano, M.
AU - Castiglia, C.
AU - de Filippo, I.
AU - Santini, G.
PY - 1984
Y1 - 1984
N2 - We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.
AB - We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021701869&partnerID=8YFLogxK
M3 - Article
VL - 33
SP - 363
EP - 367
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 4
ER -