Chronic T lymphocytic leukaemia

Antigenic, morphological and functional properties of the neoplastic lymphocytes

P. de Paoli, R. Nimis, G. L. Molaro, S. Battistin, M. Reitano, C. Castiglia, I. de Filippo, G. Santini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalScandinavian Journal of Haematology
Volume33
Issue number4
Publication statusPublished - 1984

Fingerprint

T-Cell Prolymphocytic Leukemia
Lymphocytes
Muromonab-CD3
Mitogens
Spleen
T-Cell Leukemia
Liver
Leukocyte Count
Cell Count
Lymph Nodes
Monoclonal Antibodies
T-Lymphocytes

ASJC Scopus subject areas

  • Hematology

Cite this

de Paoli, P., Nimis, R., Molaro, G. L., Battistin, S., Reitano, M., Castiglia, C., ... Santini, G. (1984). Chronic T lymphocytic leukaemia: Antigenic, morphological and functional properties of the neoplastic lymphocytes. Scandinavian Journal of Haematology, 33(4), 363-367.

Chronic T lymphocytic leukaemia : Antigenic, morphological and functional properties of the neoplastic lymphocytes. / de Paoli, P.; Nimis, R.; Molaro, G. L.; Battistin, S.; Reitano, M.; Castiglia, C.; de Filippo, I.; Santini, G.

In: Scandinavian Journal of Haematology, Vol. 33, No. 4, 1984, p. 363-367.

Research output: Contribution to journalArticle

de Paoli, P, Nimis, R, Molaro, GL, Battistin, S, Reitano, M, Castiglia, C, de Filippo, I & Santini, G 1984, 'Chronic T lymphocytic leukaemia: Antigenic, morphological and functional properties of the neoplastic lymphocytes', Scandinavian Journal of Haematology, vol. 33, no. 4, pp. 363-367.
de Paoli, P. ; Nimis, R. ; Molaro, G. L. ; Battistin, S. ; Reitano, M. ; Castiglia, C. ; de Filippo, I. ; Santini, G. / Chronic T lymphocytic leukaemia : Antigenic, morphological and functional properties of the neoplastic lymphocytes. In: Scandinavian Journal of Haematology. 1984 ; Vol. 33, No. 4. pp. 363-367.
@article{65952a466f624eacb0f85539bfccd6ea,
title = "Chronic T lymphocytic leukaemia: Antigenic, morphological and functional properties of the neoplastic lymphocytes",
abstract = "We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.",
author = "{de Paoli}, P. and R. Nimis and Molaro, {G. L.} and S. Battistin and M. Reitano and C. Castiglia and {de Filippo}, I. and G. Santini",
year = "1984",
language = "English",
volume = "33",
pages = "363--367",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",

}

TY - JOUR

T1 - Chronic T lymphocytic leukaemia

T2 - Antigenic, morphological and functional properties of the neoplastic lymphocytes

AU - de Paoli, P.

AU - Nimis, R.

AU - Molaro, G. L.

AU - Battistin, S.

AU - Reitano, M.

AU - Castiglia, C.

AU - de Filippo, I.

AU - Santini, G.

PY - 1984

Y1 - 1984

N2 - We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.

AB - We describe 2 cases of T cell leukaemia. Both patients react with OKT4 monoclonal antibody, white their clinical course, surface markers and in vitro immunological reactivity present opposite behaviour. The cells of 1 patient react with all pan T cell markers (OKT3, OKT11, Leu1), from E and Ea rosettes and respond well to mitogens. This patient does not present liver, spleen or lymph node enlargemen; while cell count is stable and no other haematological alterations are present. The cells from the 2 patients are unreactive with OKT3 and are unable to form Ea rosettes. The response to mitogens is almost abolished. The disease has an aggressive clinical course with progressively increasing blood leucocyte count and infiltration of liver and spleen. These data suggest that the study of antigenic and functional properties of T CLL may be useful to better define the biologic characteristics and the prognostic criteria of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0021701869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021701869&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 363

EP - 367

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 4

ER -