Chronic treatment with iprindole reduces immobility of rats in the behavioural 'despair' test by activating dopaminergic mechanisms in the brain

C. Berettera, R. Invernizzi, L. Pulvirenti, R. Samanin

Research output: Contribution to journalArticle

Abstract

Iprindole, 10 mg kg-1 i.p., once daily for 21 days, enhanced the metabolism of dopamine in the frontal cortex and striatum of rats with no effect in the nucleus accumbens 1 h after the last injection. Noradrenaline metabolism in the brainstem and telecephalon was also increased in these conditions. No effect on dopamine or noradrenaline metabolism was seen 24 h after the last injection. The same repeated treatment schedule with iprindole markedly reduced the immobility of rats in the behaviour 'despair' test 1 h after the last injection and the effect was prevented by 0.5 mg kg-1 i.p. haloperidol and 100 mg kg-1 i.p. sulpiride but not by 3 mg kg-1 s.c. prazosin or 5 mg kg-1 i.p. (±)-propranolol. The data show that enhanced metabolism of brain dopamine and noradrenaline is associated with the presence of iprindole during repeated treatment and the effect on dopamine mechanism is important in iprindole's ability to reduct rats' immobility in the behavioural 'despair' test.

Original languageEnglish
Pages (from-to)313-315
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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