Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

David L. Hwang, Avraham Roitman, Arye Lev-Ran, Brian I. Carr

Research output: Contribution to journalArticle

Abstract

In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number2
DOIs
Publication statusPublished - Mar 13 1986

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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