Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

David L. Hwang; Avraham Roitman; Arye Lev-Ran; Brian I. Carr

doi:10.1016/0006-291X(86)90022-7

Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

David L. Hwang, Avraham Roitman, Arye Lev-Ran, Brian I. Carr

Ente Ospedaliero Specializzato in Gastroenterologia "Saverio de Bellis"

Research output: Contribution to journal › Article › peer-review

Abstract

In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.

Original language	English
Pages (from-to)	501-506
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(86)90022-7
Publication status	Published - Mar 13 1986

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Access to Document

10.1016/0006-291X(86)90022-7

Cite this

@article{67532558ff754e54afed55b393e6907e,

title = "Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors",

abstract = "In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.",

author = "Hwang, {David L.} and Avraham Roitman and Arye Lev-Ran and Carr, {Brian I.}",

year = "1986",

month = mar,

day = "13",

doi = "10.1016/0006-291X(86)90022-7",

language = "English",

volume = "135",

pages = "501--506",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

AU - Hwang, David L.

AU - Roitman, Avraham

AU - Lev-Ran, Arye

AU - Carr, Brian I.

PY - 1986/3/13

Y1 - 1986/3/13

N2 - In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.

AB - In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.

UR - http://www.scopus.com/inward/record.url?scp=0022509118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022509118&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(86)90022-7

DO - 10.1016/0006-291X(86)90022-7

M3 - Article

C2 - 3008725

AN - SCOPUS:0022509118

VL - 135

SP - 501

EP - 506

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -

Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this