Abstract
In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.
| Original language | English |
|---|---|
| Pages (from-to) | 501-506 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 135 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 13 1986 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors. / Hwang, David L.; Roitman, Avraham; Lev-Ran, Arye; Carr, Brian I.
In: Biochemical and Biophysical Research Communications, Vol. 135, No. 2, 13.03.1986, p. 501-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors
AU - Hwang, David L.
AU - Roitman, Avraham
AU - Lev-Ran, Arye
AU - Carr, Brian I.
PY - 1986/3/13
Y1 - 1986/3/13
N2 - In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.
AB - In male F-344 rats fed phenobarbital 0.05% with chow the binding of EGF to microsomal and Golgi liver fractions decreased after 2 weeks, dropped by more than 60% after one month and remained low for the following five months of the experiment. The binding of insulin remained stable for 2 weeks after which it decreased by half. In both cases the receptors decreased in number without changes in their affinity. Autophosphorylation of the receptors showed changes parallel to those of the binding of the ligands.
UR - http://www.scopus.com/inward/record.url?scp=0022509118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022509118&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(86)90022-7
DO - 10.1016/0006-291X(86)90022-7
M3 - Article
VL - 135
SP - 501
EP - 506
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -