Sixty albino Sprague-Dawley female rats, 250 g of body weight, were treated for 6 months with phenytoin 30 mg/100 g/die per os (mean plasma levels: 10-20 γ/ml). Between 75 and 90 days of treatment, motor and sensory nerve conduction velocities were examined along the tail in 15 treated animals and in 10 untreated control animals. A slowing of sensory conduction velocity was shown in 6 treated-animals (40%); in 2 of them (13%) the motor conduction velocity was also slowed. Twenty-five treated rats were controlled with the same neurophysiologic methods after 165-180 days of PHT treatment in comparison with 10 controls; (56%) and a slowing of motor conduction in 5 of them (20%). The histological and ultrastructural study carried out on the sciatic nerves of all animals revealed changes of the myelinated fibres only in the animals with slowed motor conduction velocity.
|Title of host publication||Farmaco, Edizione Scientifica|
|Number of pages||6|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Molecular Medicine