Chronic treatment with phenytoin in rats: Effects on peripheral nervous system

A. Moglia, A. Tartara, A. Arrigo, P. Poggi, M. Scelsi, R. Scelsi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sixty albino Sprague-Dawley female rats, 250 g of body weight, were treated for 6 months with phenytoin 30 mg/100 g/die per os (mean plasma levels: 10-20 γ/ml). Between 75 and 90 days of treatment, motor and sensory nerve conduction velocities were examined along the tail in 15 treated animals and in 10 untreated control animals. A slowing of sensory conduction velocity was shown in 6 treated-animals (40%); in 2 of them (13%) the motor conduction velocity was also slowed. Twenty-five treated rats were controlled with the same neurophysiologic methods after 165-180 days of PHT treatment in comparison with 10 controls; (56%) and a slowing of motor conduction in 5 of them (20%). The histological and ultrastructural study carried out on the sciatic nerves of all animals revealed changes of the myelinated fibres only in the animals with slowed motor conduction velocity.

Original languageEnglish
Title of host publicationFarmaco, Edizione Scientifica
Pages419-424
Number of pages6
Volume36
Edition6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Molecular Medicine

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