Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice

F. De Nigris, F. P. D'Armiento, P. Somma, A. Casini, I. Andreini, F. Sarlo, G. Mansueto, G. De Rosa, D. Bonaduce, M. Condorelli, C. Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of chronic treatment with the new sulfhydryl angiotensin-converting enzyme (ACE)-inhibitor, zofenopril, in comparison with the classical sulfhydryl ACE-inhibitor captopril or enalapril or placebo on the development of atherosclerosis were determined in apolipoprotein-E knockout (apoE-/-) mice. Groups of 2-month-old male mice received either placebo (N=10), 0.05 mg/kg/day of zofenopril (N=10), 1 mg/kg/day of zofenopril (N=10), 5 mg/kg/day of captopril (N=10) or 0.5 mg/kg/day of enalapril (N=8). After 29 weeks of treatment, computer-assisted imaging analysis revealed that zofenopril reduced the aortic cumulative lesion area by 78% at 0.05 mg/kg/day and by 89% at 1 mg/ml/day of zofenopril compared to that of the placebo (P-/- mice. This protection was significantly higher than that reached with captopril and at lower doses of the drug. Treatment with 0.5 mg/kg/day of enalapril did not provide any protective effect.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalInternational Journal of Cardiology
Volume81
Issue number2-3
DOIs
Publication statusPublished - 2001

Keywords

  • Apolipoprotein E-deficient mice
  • Atherosclerosis
  • LDL
  • Oxidation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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