Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly

Bartolomeo Merola, Antonio Cittadini, Annamaria Colao, Diego Ferone, Serafino Fazio, Domenico Sabatini, Bernadette Biondi, Luigi Saccá, Gaetano Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the effects of a 6-month octreotide treatment on cardiac mass and function by means of Doppler echocardiography in 11 normotensive patients affected with active acromegaly. The GH and insulin-like growth factor-I levels were normalized during octreotide therapy from 34 ± 6.5 and 767.4 ± 72.4 μg/ L to 4.6 ± 0.9 and 235 ± 10.3 μg/L, respectively (P <0.001; mean ± SEM). After the 6-month treatment, we observed a significant decrease in the left ventricular mass index from 138 ± 11 to 116 ± 13 g/m2 (P <0.001) and in the mean wall thickness/internal end-diastolic radius ratio from 0.47 ± 0.1 to 0.44 ± 0.1 (P <0.001). No significant differences were found in systolic function indices, whereas diastolic filling indices improved over the course of the therapy; the isovolumic relaxation time decreased from 115 ± 6 to 100 ± 6 ms (P<0.05), tricuspid late diastolic filling velocities decreased from 41 ± 3 to 36 ± 2 cm/s (P <0.03), and tricuspid deceleration time decreased from 280 ± 28 to 198 ± 15 ms (P <0.005); the ratio of early to late peak velocity of the right ventricular filling significantly increased from 1 ± 0.01 to 1.3 ± 0.1 (P <0.03). A significant correlation was detected between left ventricular mass regression and increase in the early to late peak velocity ratio of the left ventricular filling (r = 0.62; P <0.05). The results of this study show an improvement in cardiac structural and functional abnormalities during chronic treatment with octreotide, thus supporting the hypothesis of a specific heart disease secondary to high circulating GH levels.

Original languageEnglish
Pages (from-to)790-793
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number3
Publication statusPublished - Sep 1993

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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