Chronic urticaria and drug hypersensitivity in children

Carla Mastrorilli, Roberto Bernardini, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Francesca Mori, Fabio Cardinale, Francesca Saretta, Giovanni Simeone, Marcello Bergamini, Carlo Caffarelli

Research output: Contribution to journalReview articlepeer-review


The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. The diagnostic work-up of chronic urticaria includes a comprehensive evaluation of triggering factors such as drugs. A diagnosis is necessary in order to permit a safely administration of drugs in children with chronic urticaria. (

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalActa Biomedica
Publication statusPublished - Jan 1 2019


  • Basophil activation tesdrug provocation test
  • Children
  • Drug hypersensitivity reactions
  • Skin test
  • Specific IgE
  • Urticaria

ASJC Scopus subject areas

  • Medicine(all)


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