Chronic viral hepatitis

The histology report

Maria Guido, Alessandra Mangia, Gavino Faa

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In chronic viral hepatitis, the role of liver biopsy as a diagnostic test has seen a decline, paralleled by its increasing importance for prognostic purposes. Nowadays, the main indication for liver biopsy in chronic viral hepatitis is to assess the severity of the disease, in terms of both necro-inflammation (grade) and fibrosis (stage), which is important for prognosis and therapeutic management. Several scoring systems have been proposed for grading and staging chronic viral hepatitis and there is no a general consensus on the best system to be used in the daily practice. All scoring systems have their drawbacks and all may be affected by sampling and observer variability. Whatever the system used, a histological score is a reductive approach since damage in chronic viral hepatitis is a complex biological process. Thus, scoring systems are not intended to replace the detailed, descriptive, pathology report. In fact, lesions other than those scored for grading and staging may have clinical relevance and should be assessed and reported. This paper aims to provide a systematic approach to the interpretation of liver biopsies obtained in cases of chronic viral hepatitis, with the hope of helping general pathologists in their diagnostic practice.

Original languageEnglish
JournalDigestive and Liver Disease
Volume43
Issue numberSUPPL. 4
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Chronic Hepatitis
Histology
Biopsy
Liver
Biological Phenomena
Routine Diagnostic Tests
Fibrosis
Pathology
Inflammation

Keywords

  • Chronic viral hepatitis
  • GIPAD report
  • Liver biopsy
  • Scoring systems

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Chronic viral hepatitis : The histology report. / Guido, Maria; Mangia, Alessandra; Faa, Gavino.

In: Digestive and Liver Disease, Vol. 43, No. SUPPL. 4, 03.2011.

Research output: Contribution to journalArticle

Guido, Maria ; Mangia, Alessandra ; Faa, Gavino. / Chronic viral hepatitis : The histology report. In: Digestive and Liver Disease. 2011 ; Vol. 43, No. SUPPL. 4.
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