Chronic widespread pain: From peripheral to central evolution

Piercarlo Sarzi-Puttini; Fabiola Atzeni; Philip J. Mease

doi:10.1016/j.berh.2011.04.001

Chronic widespread pain: From peripheral to central evolution

Piercarlo Sarzi-Puttini, Fabiola Atzeni, Philip J. Mease

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article

Abstract

Chronic pain can be classified as localised, regional or widespread, and its high prevalence in the general population seems to increase with age. The majority of cases present with musculoskeletal pain. The conditions associated with chronic widespread pain (CWP) are highly burdensome as their characteristic symptoms may include multifocal pain, fatigue, insomnia, memory difficulties and a higher rate of concomitant mood disorders. After many years of debate, it is still unclear whether CWP (central sensitisation) is an entirely explainable neurotransmitter-related process or is partially or totally due to individual cognitive experiences and evaluations. The two models (neurochemical and biopsychosocial) also affect our ability to find therapeutic answers.

Original language	English
Pages (from-to)	133-139
Number of pages	7
Journal	Best Practice and Research: Clinical Rheumatology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.berh.2011.04.001
Publication status	Published - Apr 2011

Keywords

Central
Chronic widespread pain
Fibromyalgia
Pain
Sensitisation

ASJC Scopus subject areas

Rheumatology

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10.1016/j.berh.2011.04.001

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Sarzi-Puttini, P., Atzeni, F., & Mease, P. J. (2011). Chronic widespread pain: From peripheral to central evolution. Best Practice and Research: Clinical Rheumatology, 25(2), 133-139. https://doi.org/10.1016/j.berh.2011.04.001

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