TY - JOUR
T1 - Chronic widespread pain
T2 - From peripheral to central evolution
AU - Sarzi-Puttini, Piercarlo
AU - Atzeni, Fabiola
AU - Mease, Philip J.
PY - 2011/4
Y1 - 2011/4
N2 - Chronic pain can be classified as localised, regional or widespread, and its high prevalence in the general population seems to increase with age. The majority of cases present with musculoskeletal pain. The conditions associated with chronic widespread pain (CWP) are highly burdensome as their characteristic symptoms may include multifocal pain, fatigue, insomnia, memory difficulties and a higher rate of concomitant mood disorders. After many years of debate, it is still unclear whether CWP (central sensitisation) is an entirely explainable neurotransmitter-related process or is partially or totally due to individual cognitive experiences and evaluations. The two models (neurochemical and biopsychosocial) also affect our ability to find therapeutic answers.
AB - Chronic pain can be classified as localised, regional or widespread, and its high prevalence in the general population seems to increase with age. The majority of cases present with musculoskeletal pain. The conditions associated with chronic widespread pain (CWP) are highly burdensome as their characteristic symptoms may include multifocal pain, fatigue, insomnia, memory difficulties and a higher rate of concomitant mood disorders. After many years of debate, it is still unclear whether CWP (central sensitisation) is an entirely explainable neurotransmitter-related process or is partially or totally due to individual cognitive experiences and evaluations. The two models (neurochemical and biopsychosocial) also affect our ability to find therapeutic answers.
KW - Central
KW - Chronic widespread pain
KW - Fibromyalgia
KW - Pain
KW - Sensitisation
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U2 - 10.1016/j.berh.2011.04.001
DO - 10.1016/j.berh.2011.04.001
M3 - Article
C2 - 22094190
AN - SCOPUS:81355160945
VL - 25
SP - 133
EP - 139
JO - Best Practice and Research in Clinical Rheumatology
JF - Best Practice and Research in Clinical Rheumatology
SN - 1521-6942
IS - 2
ER -