"chronic"metastatic pancreatic acinar cell carcinoma

Ferdinando C M Cananzi, Akali Jayanth, Bruno Lorenzi, Ajay Belgaumkar, Kazimiriez Mochlinski, Anand Sharma, Satvinder Mudan, David Cunningham

Research output: Contribution to journalArticlepeer-review


Acinar cell carcinoma (ACC) of the pancreas is a rare exocrine tumour for which there is very limited information about chemotherapy regimens and prognosis. Even though there are clinical guidelines for management of ductal cell carcinoma, a definitive and specific regime has not yet been agreed for this type of pancreatic cancer. We report a case of metastatic ACC of pancreas who has been treated with a multimodal approach, including novel combinations of different targeted drugs with conventional chemotherapy, surgery and radiofrequency ablation since the last 11 years. This degree of long term survival has not been reported so far in such a case of metastatic ACC of the pancreas. This case highlights the importance of a personalised multidisciplinary therapeutic strategy, employing locoregional therapies along with combinations of established and novel systemic therapies to control the disease, and the importance of flexibility when instigating new treatment paradigms for progressive cancer. Also, this case demonstrates that complete tumour eradication may not be the sole purpose of surgical oncology.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
Issue number5
Publication statusPublished - Sep 2013


  • Acinar cell carcinoma
  • Long survival
  • Metastatic pancreatic cancer
  • Surgery
  • Targeted therapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology


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