Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients

Ana Luiza Lunardi Rocha, Federico Lombardi, Manoel Otávio Da Costa Rocha, Márcio Vinícius Lins Barros, Vladimir Da Costa Val Barros, Adelina Martha Reis, Antonio Luiz Pinho Ribeiro

Research output: Contribution to journalArticle

Abstract

Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalAnnals of Noninvasive Electrocardiology
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2006

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Chagas Disease
Heart Rate
Exercise
Ambulatory Electrocardiography
Doppler Echocardiography
Brain Natriuretic Peptide
Left Ventricular Dysfunction

Keywords

  • Autonomic nervous system
  • Chagas disease
  • Chronotropic incompetence
  • Exercise test
  • Heart rate variability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Rocha, A. L. L., Lombardi, F., Da Costa Rocha, M. O., Barros, M. V. L., Val Barros, V. D. C., Reis, A. M., & Ribeiro, A. L. P. (2006). Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients. Annals of Noninvasive Electrocardiology, 11(1), 3-11. https://doi.org/10.1111/j.1542-474X.2006.00054.x

Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients. / Rocha, Ana Luiza Lunardi; Lombardi, Federico; Da Costa Rocha, Manoel Otávio; Barros, Márcio Vinícius Lins; Val Barros, Vladimir Da Costa; Reis, Adelina Martha; Ribeiro, Antonio Luiz Pinho.

In: Annals of Noninvasive Electrocardiology, Vol. 11, No. 1, 01.2006, p. 3-11.

Research output: Contribution to journalArticle

Rocha, Ana Luiza Lunardi ; Lombardi, Federico ; Da Costa Rocha, Manoel Otávio ; Barros, Márcio Vinícius Lins ; Val Barros, Vladimir Da Costa ; Reis, Adelina Martha ; Ribeiro, Antonio Luiz Pinho. / Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients. In: Annals of Noninvasive Electrocardiology. 2006 ; Vol. 11, No. 1. pp. 3-11.
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