Abstract
Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (
| Original language | English |
|---|---|
| Pages (from-to) | 3-11 |
| Number of pages | 9 |
| Journal | Annals of Noninvasive Electrocardiology |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
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Keywords
- Autonomic nervous system
- Chagas disease
- Chronotropic incompetence
- Exercise test
- Heart rate variability
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients. / Rocha, Ana Luiza Lunardi; Lombardi, Federico; Da Costa Rocha, Manoel Otávio; Barros, Márcio Vinícius Lins; Val Barros, Vladimir Da Costa; Reis, Adelina Martha; Ribeiro, Antonio Luiz Pinho.
In: Annals of Noninvasive Electrocardiology, Vol. 11, No. 1, 01.2006, p. 3-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients
AU - Rocha, Ana Luiza Lunardi
AU - Lombardi, Federico
AU - Da Costa Rocha, Manoel Otávio
AU - Barros, Márcio Vinícius Lins
AU - Val Barros, Vladimir Da Costa
AU - Reis, Adelina Martha
AU - Ribeiro, Antonio Luiz Pinho
PY - 2006/1
Y1 - 2006/1
N2 - Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (
AB - Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (
KW - Autonomic nervous system
KW - Chagas disease
KW - Chronotropic incompetence
KW - Exercise test
KW - Heart rate variability
UR - http://www.scopus.com/inward/record.url?scp=33644976893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644976893&partnerID=8YFLogxK
U2 - 10.1111/j.1542-474X.2006.00054.x
DO - 10.1111/j.1542-474X.2006.00054.x
M3 - Article
C2 - 16472276
AN - SCOPUS:33644976893
VL - 11
SP - 3
EP - 11
JO - Annals of Noninvasive Electrocardiology
JF - Annals of Noninvasive Electrocardiology
SN - 1082-720X
IS - 1
ER -