Chronotropic incompetence and abnormal autonomic modulation in ambulatory chagas disease patients

Ana Luiza Lunardi Rocha, Federico Lombardi, Manoel Otávio Da Costa Rocha, Márcio Vinícius Lins Barros, Vladimir Da Costa Val Barros, Adelina Martha Reis, Antonio Luiz Pinho Ribeiro

Research output: Contribution to journalArticlepeer-review


Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalAnnals of Noninvasive Electrocardiology
Issue number1
Publication statusPublished - Jan 2006


  • Autonomic nervous system
  • Chagas disease
  • Chronotropic incompetence
  • Exercise test
  • Heart rate variability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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