Chronotype influences response to antidepressant chronotherapeutics in bipolar patients

S Dallaspezia, M Suzuki, C Locatelli, C Colombo, F Benedetti

Research output: Contribution to journalArticlepeer-review


Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep homeostasis predict antidepressant response to the combination of total sleep deprivation and light therapy (TSD + LT). In order to study if chronotype could influence response to TSD+LT, we considered 194 bipolar depressed patients. Severity of depression was rated with Hamilton Depression Rating Scale; perceived mood levels were assessed by a self-administered 10-cm visual analogue scale and chronotype was assessed using the Mornigness-Eveningness Questionnaire. More than 60% of patients resulted responders to treatment with chronotype influencing the antidepressant response with evening type subjects showing higher response rates. © 2018 Taylor & Francis Group, LLC
Original languageEnglish
Pages (from-to)1319-1325
Number of pages7
JournalChronobiology International
Issue number9
Publication statusPublished - 2018


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