Churg-Strauss Syndrome: A diagnosis not to be forgotten

Domenico Zanaboni, Anna Maccabruni, Eleonora Bonacci, Marta Caprioli, Roberto Caporali, Bianca Mariani

Research output: Contribution to journalArticle

Abstract

Churg-Strauss syndrome (CSS) is a peculiar form of vasculitis with involvement of small- and medium-size arteries, histologically characterized by necrotizing granulomas in vessel walls and in perivascular tissues. The Authors report a case of CSS occurred in a young man being treated with corticosteroids for a diagnosis of asthma. The patient was hospitalized because of fever, diarrhoea and abdominal pain; the first assessment showed leucocytosis and eosinophilia, increase in flogosis indexes and anti-pANCA antibodies positive. A few days later an acute peritonitis with multiple intestinal perforations occurred and a partial resection of small bowel was performed, followed by another resection of an ileal segment because of a new double perforation close to the previous intestinal anastomosis. In the bowel resection pieces necrotizing vasculitis and granulomatous infiltrates involving lymphocytes and eosino- phils were observed. Although the severe intestinal involvement and especially the symptoms necessitating iterative surgery were significant factors of poor prognosis the patient was successfully treated firstly with metylprednisolone only and then with monthly administration of immunosuppressive drugs combined with lower daily dose of steroids. The CSS diagnosis is not to be forgotten althoughits early clinical features can be frequently mistaken for an allergic disease; an early diagnosis can allow to perform the best treatment, to reach the disease remission and to improve the quality of life of the patients.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalNew Microbiologica
Volume31
Issue number2
Publication statusPublished - Apr 2008

Fingerprint

Churg-Strauss Syndrome
Vasculitis
Intestinal Perforation
Leukocytosis
Eosinophilia
Immunosuppressive Agents
Granuloma
Peritonitis
Eosinophils
Abdominal Pain
Early Diagnosis
Anti-Idiotypic Antibodies
Diarrhea
Adrenal Cortex Hormones
Fever
Asthma
Arteries
Steroids
Quality of Life
Lymphocytes

Keywords

  • Churg-Strauss vasculitis steroids

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Churg-Strauss Syndrome : A diagnosis not to be forgotten. / Zanaboni, Domenico; Maccabruni, Anna; Bonacci, Eleonora; Caprioli, Marta; Caporali, Roberto; Mariani, Bianca.

In: New Microbiologica, Vol. 31, No. 2, 04.2008, p. 285-290.

Research output: Contribution to journalArticle

Zanaboni, D, Maccabruni, A, Bonacci, E, Caprioli, M, Caporali, R & Mariani, B 2008, 'Churg-Strauss Syndrome: A diagnosis not to be forgotten', New Microbiologica, vol. 31, no. 2, pp. 285-290.
Zanaboni, Domenico ; Maccabruni, Anna ; Bonacci, Eleonora ; Caprioli, Marta ; Caporali, Roberto ; Mariani, Bianca. / Churg-Strauss Syndrome : A diagnosis not to be forgotten. In: New Microbiologica. 2008 ; Vol. 31, No. 2. pp. 285-290.
@article{cc970b7f09744e62862358e02f98b097,
title = "Churg-Strauss Syndrome: A diagnosis not to be forgotten",
abstract = "Churg-Strauss syndrome (CSS) is a peculiar form of vasculitis with involvement of small- and medium-size arteries, histologically characterized by necrotizing granulomas in vessel walls and in perivascular tissues. The Authors report a case of CSS occurred in a young man being treated with corticosteroids for a diagnosis of asthma. The patient was hospitalized because of fever, diarrhoea and abdominal pain; the first assessment showed leucocytosis and eosinophilia, increase in flogosis indexes and anti-pANCA antibodies positive. A few days later an acute peritonitis with multiple intestinal perforations occurred and a partial resection of small bowel was performed, followed by another resection of an ileal segment because of a new double perforation close to the previous intestinal anastomosis. In the bowel resection pieces necrotizing vasculitis and granulomatous infiltrates involving lymphocytes and eosino- phils were observed. Although the severe intestinal involvement and especially the symptoms necessitating iterative surgery were significant factors of poor prognosis the patient was successfully treated firstly with metylprednisolone only and then with monthly administration of immunosuppressive drugs combined with lower daily dose of steroids. The CSS diagnosis is not to be forgotten althoughits early clinical features can be frequently mistaken for an allergic disease; an early diagnosis can allow to perform the best treatment, to reach the disease remission and to improve the quality of life of the patients.",
keywords = "Churg-Strauss vasculitis steroids",
author = "Domenico Zanaboni and Anna Maccabruni and Eleonora Bonacci and Marta Caprioli and Roberto Caporali and Bianca Mariani",
year = "2008",
month = "4",
language = "English",
volume = "31",
pages = "285--290",
journal = "New Microbiologica",
issn = "1121-7138",
publisher = "Luigi Ponzio e figlio Editori",
number = "2",

}

TY - JOUR

T1 - Churg-Strauss Syndrome

T2 - A diagnosis not to be forgotten

AU - Zanaboni, Domenico

AU - Maccabruni, Anna

AU - Bonacci, Eleonora

AU - Caprioli, Marta

AU - Caporali, Roberto

AU - Mariani, Bianca

PY - 2008/4

Y1 - 2008/4

N2 - Churg-Strauss syndrome (CSS) is a peculiar form of vasculitis with involvement of small- and medium-size arteries, histologically characterized by necrotizing granulomas in vessel walls and in perivascular tissues. The Authors report a case of CSS occurred in a young man being treated with corticosteroids for a diagnosis of asthma. The patient was hospitalized because of fever, diarrhoea and abdominal pain; the first assessment showed leucocytosis and eosinophilia, increase in flogosis indexes and anti-pANCA antibodies positive. A few days later an acute peritonitis with multiple intestinal perforations occurred and a partial resection of small bowel was performed, followed by another resection of an ileal segment because of a new double perforation close to the previous intestinal anastomosis. In the bowel resection pieces necrotizing vasculitis and granulomatous infiltrates involving lymphocytes and eosino- phils were observed. Although the severe intestinal involvement and especially the symptoms necessitating iterative surgery were significant factors of poor prognosis the patient was successfully treated firstly with metylprednisolone only and then with monthly administration of immunosuppressive drugs combined with lower daily dose of steroids. The CSS diagnosis is not to be forgotten althoughits early clinical features can be frequently mistaken for an allergic disease; an early diagnosis can allow to perform the best treatment, to reach the disease remission and to improve the quality of life of the patients.

AB - Churg-Strauss syndrome (CSS) is a peculiar form of vasculitis with involvement of small- and medium-size arteries, histologically characterized by necrotizing granulomas in vessel walls and in perivascular tissues. The Authors report a case of CSS occurred in a young man being treated with corticosteroids for a diagnosis of asthma. The patient was hospitalized because of fever, diarrhoea and abdominal pain; the first assessment showed leucocytosis and eosinophilia, increase in flogosis indexes and anti-pANCA antibodies positive. A few days later an acute peritonitis with multiple intestinal perforations occurred and a partial resection of small bowel was performed, followed by another resection of an ileal segment because of a new double perforation close to the previous intestinal anastomosis. In the bowel resection pieces necrotizing vasculitis and granulomatous infiltrates involving lymphocytes and eosino- phils were observed. Although the severe intestinal involvement and especially the symptoms necessitating iterative surgery were significant factors of poor prognosis the patient was successfully treated firstly with metylprednisolone only and then with monthly administration of immunosuppressive drugs combined with lower daily dose of steroids. The CSS diagnosis is not to be forgotten althoughits early clinical features can be frequently mistaken for an allergic disease; an early diagnosis can allow to perform the best treatment, to reach the disease remission and to improve the quality of life of the patients.

KW - Churg-Strauss vasculitis steroids

UR - http://www.scopus.com/inward/record.url?scp=46649120715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46649120715&partnerID=8YFLogxK

M3 - Article

C2 - 18623996

AN - SCOPUS:46649120715

VL - 31

SP - 285

EP - 290

JO - New Microbiologica

JF - New Microbiologica

SN - 1121-7138

IS - 2

ER -