Churg-Strauss syndrome: Clinical and serological features of 19 patients from a single Italian centre

A. Della Rossa, C. Baldini, A. Tavoni, A. Tognetti, D. Neglia, G. Sambuceti, R. Puccini, C. Colangelo, S. Bombardieri

Research output: Contribution to journalArticle

Abstract

Objective. Churg-Strauss syndrome is a rare multisystem vasculitis of unknown aetiology. Due to the rarity of the disease, few single-centre case series have been described. The aim of this study was to evaluate a small series from a single Italian centre in order to describe the clinical features of the disease, the treatment and long-term follow-up. Methods. Nineteen Churg-Strauss syndrome patients were selected from the medical records of all vasculitis patients attending the Immunology Unit at the Department of Internal Medicine of the University of Pisa in the decade between 1989 and 2000. Data were obtained retrospectively. Results. All the patients had asthma and hypereosinophilia. As in other case series, the lungs, skin and peripheral nervous system were the most commonly involved organs. The majority of our patient received i.v. pulses of methylprednisolone followed by i.v. pulses of cyclophosphamide. The outcome and long-term follow-up were good. There were no fatalities observed in this series during the follow-up period. Conclusions. Churg-Strauss syndrome is a systemic vasculitis occurring in patients with a history of asthma and allergic rhinitis. The positive results of the treatment protocol used in this preliminary study deserve to be tested in controlled multicentre studies.

Original languageEnglish
Pages (from-to)1286-1294
Number of pages9
JournalRheumatology
Volume41
Issue number11
Publication statusPublished - Nov 1 2002

Fingerprint

Churg-Strauss Syndrome
Vasculitis
Asthma
Systemic Vasculitis
Methylprednisolone
Peripheral Nervous System
Internal Medicine
Clinical Protocols
Allergy and Immunology
Cyclophosphamide
Multicenter Studies
Medical Records
Lung
Skin

Keywords

  • Churg-Strauss syndrome
  • Italian centre
  • Long-term follow-up
  • Retrospective study
  • Treatment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Della Rossa, A., Baldini, C., Tavoni, A., Tognetti, A., Neglia, D., Sambuceti, G., ... Bombardieri, S. (2002). Churg-Strauss syndrome: Clinical and serological features of 19 patients from a single Italian centre. Rheumatology, 41(11), 1286-1294.

Churg-Strauss syndrome : Clinical and serological features of 19 patients from a single Italian centre. / Della Rossa, A.; Baldini, C.; Tavoni, A.; Tognetti, A.; Neglia, D.; Sambuceti, G.; Puccini, R.; Colangelo, C.; Bombardieri, S.

In: Rheumatology, Vol. 41, No. 11, 01.11.2002, p. 1286-1294.

Research output: Contribution to journalArticle

Della Rossa, A, Baldini, C, Tavoni, A, Tognetti, A, Neglia, D, Sambuceti, G, Puccini, R, Colangelo, C & Bombardieri, S 2002, 'Churg-Strauss syndrome: Clinical and serological features of 19 patients from a single Italian centre', Rheumatology, vol. 41, no. 11, pp. 1286-1294.
Della Rossa A, Baldini C, Tavoni A, Tognetti A, Neglia D, Sambuceti G et al. Churg-Strauss syndrome: Clinical and serological features of 19 patients from a single Italian centre. Rheumatology. 2002 Nov 1;41(11):1286-1294.
Della Rossa, A. ; Baldini, C. ; Tavoni, A. ; Tognetti, A. ; Neglia, D. ; Sambuceti, G. ; Puccini, R. ; Colangelo, C. ; Bombardieri, S. / Churg-Strauss syndrome : Clinical and serological features of 19 patients from a single Italian centre. In: Rheumatology. 2002 ; Vol. 41, No. 11. pp. 1286-1294.
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