Chylous effusions due to neuroblastoma resolved by intrapleural chlorambucil coupled to father's antibodies

G. Melino, Z. B. Tabara, J. R. Hobbs

Research output: Contribution to journalArticle

Abstract

A 2-year-old boy presented with a stage IV neuroblastoma and, despite surgical reduction of the tumor mass followed by chemotherapy and radiotherapy, he developed bilateral chylous pleural effusions. These proved resistant to traditional methods of treatment but were resolved with minimal discomfort to the child by intrapleural injections of chlorambucil chemically bound to antibodies raised by immunizing his father with irradiated tumor cells.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalJournal of Pediatric Surgery
Volume20
Issue number2
DOIs
Publication statusPublished - 1985

Keywords

  • chylous effusion
  • immuno-directed chemotherapy
  • Neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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