Chylous effusions due to neuroblastoma resolved by intrapleural chlorambucil coupled to father's antibodies

G. Melino; Z. B. Tabara; J. R. Hobbs

doi:10.1016/S0022-3468(85)80298-0

Chylous effusions due to neuroblastoma resolved by intrapleural chlorambucil coupled to father's antibodies

G. Melino, Z. B. Tabara, J. R. Hobbs

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

A 2-year-old boy presented with a stage IV neuroblastoma and, despite surgical reduction of the tumor mass followed by chemotherapy and radiotherapy, he developed bilateral chylous pleural effusions. These proved resistant to traditional methods of treatment but were resolved with minimal discomfort to the child by intrapleural injections of chlorambucil chemically bound to antibodies raised by immunizing his father with irradiated tumor cells.

Original language	English
Pages (from-to)	179-181
Number of pages	3
Journal	Journal of Pediatric Surgery
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3468(85)80298-0
Publication status	Published - 1985

Keywords

chylous effusion
immuno-directed chemotherapy
Neuroblastoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery

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10.1016/S0022-3468(85)80298-0

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abstract = "A 2-year-old boy presented with a stage IV neuroblastoma and, despite surgical reduction of the tumor mass followed by chemotherapy and radiotherapy, he developed bilateral chylous pleural effusions. These proved resistant to traditional methods of treatment but were resolved with minimal discomfort to the child by intrapleural injections of chlorambucil chemically bound to antibodies raised by immunizing his father with irradiated tumor cells.",

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AU - Tabara, Z. B.

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AB - A 2-year-old boy presented with a stage IV neuroblastoma and, despite surgical reduction of the tumor mass followed by chemotherapy and radiotherapy, he developed bilateral chylous pleural effusions. These proved resistant to traditional methods of treatment but were resolved with minimal discomfort to the child by intrapleural injections of chlorambucil chemically bound to antibodies raised by immunizing his father with irradiated tumor cells.

KW - chylous effusion

KW - immuno-directed chemotherapy

KW - Neuroblastoma

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Chylous effusions due to neuroblastoma resolved by intrapleural chlorambucil coupled to father's antibodies

Abstract

Keywords

ASJC Scopus subject areas

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