An experimental study on rats in order to discovery any possible interaction between Ciclosporin (CyA) and H2 receptor antagonists has been carred out. The results obtained demonstrated that the serum levels of CyA were higher in rats treated with Cya and Cimetidine of Ranitidine, but not Famotidine. It is probable that the increase of ciclosporinaemia is the consequence of an increased hepatotoxicity due to administration of CyA in association with Cimetidine or Ranitidine.
|Translated title of the contribution||Ciclosporin (CyA) and H2-receptor antagonists|
|Number of pages||4|
|Publication status||Published - 1990|
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