Cigarette smoke condensate affects monocyte interaction with endothelium

I. Giunzioni, A. Bonomo, E. Bishop, S. Castiglioni, A. Corsini, S. Bellosta

Research output: Contribution to journalArticle


Objective: Circulating monocytes adhere to the endothelium and migrate into the intima contributing to atherosclerotic plaque growth. Cigarette smoke is a risk factor for atherosclerosis, but it is not completely known how it affects monocyte behavior in atherogenesis. Methods: We studied the effects of cigarette smoke condensate (CSC) on human monocytes (HM) chemotaxis and transmigration through an endothelial cell (EC) monolayer. Results: Pre-treatment with CSC caused a decrease in HM chemotaxis and transmigration (-55% and-18% vs control, p

Original languageEnglish
Pages (from-to)383-390
Number of pages8
Issue number2
Publication statusPublished - 2014


  • Cigarette smoke
  • Endothelium
  • Macrophages
  • Monocytes
  • Transmigration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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  • Cite this

    Giunzioni, I., Bonomo, A., Bishop, E., Castiglioni, S., Corsini, A., & Bellosta, S. (2014). Cigarette smoke condensate affects monocyte interaction with endothelium. Atherosclerosis, 234(2), 383-390.