Cigarette smoke condensate affects monocyte interaction with endothelium

I. Giunzioni, A. Bonomo, E. Bishop, S. Castiglioni, A. Corsini, S. Bellosta

Research output: Contribution to journalArticle

Abstract

Objective: Circulating monocytes adhere to the endothelium and migrate into the intima contributing to atherosclerotic plaque growth. Cigarette smoke is a risk factor for atherosclerosis, but it is not completely known how it affects monocyte behavior in atherogenesis. Methods: We studied the effects of cigarette smoke condensate (CSC) on human monocytes (HM) chemotaxis and transmigration through an endothelial cell (EC) monolayer. Results: Pre-treatment with CSC caused a decrease in HM chemotaxis and transmigration (-55% and-18% vs control, p

Original languageEnglish
Pages (from-to)383-390
Number of pages8
JournalAtherosclerosis
Volume234
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Cigarette smoke
  • Endothelium
  • Macrophages
  • Monocytes
  • Transmigration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Cigarette smoke condensate affects monocyte interaction with endothelium'. Together they form a unique fingerprint.

  • Cite this

    Giunzioni, I., Bonomo, A., Bishop, E., Castiglioni, S., Corsini, A., & Bellosta, S. (2014). Cigarette smoke condensate affects monocyte interaction with endothelium. Atherosclerosis, 234(2), 383-390. https://doi.org/10.1016/j.atherosclerosis.2014.03.029