Cigarette Smoking and Adenomatous Polyps: A Meta-analysis

Edoardo Botteri, Simona Iodice, Sara Raimondi, Patrick Maisonneuve, Albert B. Lowenfels

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Background & Aims: Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown. We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps. Methods: We performed a comprehensive literature search of studies linking cigarette smoking and adenomas. We used random effects models to evaluate pooled relative risks and performed dose-response, heterogeneity, publication bias, and sensitivity analyses. Results: Forty-two independent observational studies were included in the analysis. The pooled risk estimates for current, former, and ever smokers in comparison with never smokers were 2.14 (95% confidence interval [CI], 1.86-2.46), 1.47 (95% CI, 1.29-1.67), and 1.82 (95% CI, 1.65-2.00), respectively. The association was stronger for high-risk adenomas than for low-risk adenomas. Studies in which all controls underwent full colonoscopy showed a higher risk compared with studies in which some or all controls underwent partial colon examination. Conclusions: This meta-analysis provides strong evidence of the detrimental effect of cigarette smoking on the development of adenomatous polyps. Smoking is important for both formation and aggressiveness of adenomas.

Original languageEnglish
JournalGastroenterology
Volume134
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Adenomatous Polyps
Meta-Analysis
Smoking
Adenoma
Confidence Intervals
Publication Bias
Population Characteristics
Colonoscopy
Polyps
Observational Studies
Colorectal Neoplasms
Colon

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cigarette Smoking and Adenomatous Polyps : A Meta-analysis. / Botteri, Edoardo; Iodice, Simona; Raimondi, Sara; Maisonneuve, Patrick; Lowenfels, Albert B.

In: Gastroenterology, Vol. 134, No. 2, 02.2008.

Research output: Contribution to journalArticle

Botteri, Edoardo ; Iodice, Simona ; Raimondi, Sara ; Maisonneuve, Patrick ; Lowenfels, Albert B. / Cigarette Smoking and Adenomatous Polyps : A Meta-analysis. In: Gastroenterology. 2008 ; Vol. 134, No. 2.
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