Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Delphine Praud, Matteo Rota, Claudio Pelucchi, Paola Bertuccio, Tiziana Rosso, Carlotta Galeone, Zuo Feng Zhang, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C. Johnson, Guo Pei Yu, Domenico Palli, M. Ferraroni, Joshua Muscat, N. Lunet, Bárbara Peleteiro, Reza Malekzadeh, W. Ye, Huan SongDavid Zaridze, Dmitry Maximovitch, Nuria Aragonés, Gemma Castaño-Vinyals, Jesus Vioque, Eva Maria Navarrete-Muñoz, Mohammadreza Pakseresht, Farhad Pourfarzi, Alicja Wolk, Nicola Orsini, Andrea Bellavia, Niclas Hakansson, Lina Mu, Roberta Pastorino, Robert C. Kurtz, Mohammad H. Derakhshan, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Vanna Lorenza Negri, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the ‘Stomach cancer Pooling (StoP) Project’, including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09–1.32) for ever, 1.12 (95% CI: 0.99–1.27) for former, and 1.25 (95% CI: 1.11–1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10–1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14–1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

Original languageEnglish
JournalEuropean Journal of Cancer Prevention
DOIs
Publication statusAccepted/In press - Aug 24 2016

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Praud, D., Rota, M., Pelucchi, C., Bertuccio, P., Rosso, T., Galeone, C., Zhang, Z. F., Matsuo, K., Ito, H., Hu, J., Johnson, K. C., Yu, G. P., Palli, D., Ferraroni, M., Muscat, J., Lunet, N., Peleteiro, B., Malekzadeh, R., Ye, W., ... La Vecchia, C. (Accepted/In press). Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. European Journal of Cancer Prevention. https://doi.org/10.1097/CEJ.0000000000000290