Cigarette smoking and platelet function

Bianca Marasini; Maria Luisa Biondi; Silvia Barbesti; Giorgio Zatta; Angelo Agostoni

doi:10.1016/0049-3848(86)90183-0

Cigarette smoking and platelet function

Bianca Marasini, Maria Luisa Biondi, Silvia Barbesti, Giorgio Zatta, Angelo Agostoni

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

To assess the influence of cigarette smoking on platelet activation, we studied the changes in intraplatelet and platelet-released serotonin (5-HT) and plasma levels and platelet-associated production of thromboxane B2 (TXB2), in 6 non smokers and 6 habitual smokers, before and after acute exposure to smoke. Before smoking, habitual smokers showed slightly higher, albeit not significantly, 5-HT platelet concentrations and TXB2 plasma levels, as well as lower TXB2 platelet production after collagen and even more after ADP stimulation (0.59±0.27 vs 1.35±0.46 and 0.99+0.47 vs 2.08±0.51 ng/108 platelets for habitual smokers vs controls, 4 and 10 min after ADP, p

Original language	English
Pages (from-to)	85-94
Number of pages	10
Journal	Thrombosis Research
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0049-3848(86)90183-0
Publication status	Published - Oct 1 1986

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Keywords

Cigarette smoking
Platelet function
Serotonin
Thromboxane

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

Cite this

Marasini, B., Biondi, M. L., Barbesti, S., Zatta, G., & Agostoni, A. (1986). Cigarette smoking and platelet function. Thrombosis Research, 44(1), 85-94. https://doi.org/10.1016/0049-3848(86)90183-0

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10.1016/0049-3848(86)90183-0