Abstract
To assess the influence of cigarette smoking on platelet activation, we studied the changes in intraplatelet and platelet-released serotonin (5-HT) and plasma levels and platelet-associated production of thromboxane B2 (TXB2), in 6 non smokers and 6 habitual smokers, before and after acute exposure to smoke. Before smoking, habitual smokers showed slightly higher, albeit not significantly, 5-HT platelet concentrations and TXB2 plasma levels, as well as lower TXB2 platelet production after collagen and even more after ADP stimulation (0.59±0.27 vs 1.35±0.46 and 0.99+0.47 vs 2.08±0.51 ng/108 platelets for habitual smokers vs controls, 4 and 10 min after ADP, p
Original language | English |
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Pages (from-to) | 85-94 |
Number of pages | 10 |
Journal | Thrombosis Research |
Volume | 44 |
Issue number | 1 |
DOIs | |
Publication status | Published - Oct 1 1986 |
Keywords
- Cigarette smoking
- Platelet function
- Serotonin
- Thromboxane
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology