Cigarette smoking and platelet function

Bianca Marasini, Maria Luisa Biondi, Silvia Barbesti, Giorgio Zatta, Angelo Agostoni

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the influence of cigarette smoking on platelet activation, we studied the changes in intraplatelet and platelet-released serotonin (5-HT) and plasma levels and platelet-associated production of thromboxane B2 (TXB2), in 6 non smokers and 6 habitual smokers, before and after acute exposure to smoke. Before smoking, habitual smokers showed slightly higher, albeit not significantly, 5-HT platelet concentrations and TXB2 plasma levels, as well as lower TXB2 platelet production after collagen and even more after ADP stimulation (0.59±0.27 vs 1.35±0.46 and 0.99+0.47 vs 2.08±0.51 ng/108 platelets for habitual smokers vs controls, 4 and 10 min after ADP, p

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalThrombosis Research
Volume44
Issue number1
DOIs
Publication statusPublished - Oct 1 1986

Keywords

  • Cigarette smoking
  • Platelet function
  • Serotonin
  • Thromboxane

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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