Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study

Inger T. Gram, Annekatrin Lukanova, Ilene Brill, Tonje Braaten, Eiliv Lund, Eva Lundin, Kim Overvad, Anne Tjã̧nneland, Francoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Christina Bamia, Antonia Trichopoulou, Dimosthenis Zylis, Giovanna Masala, Franco Berrino, Rocco Galasso, Rosario Tumino, Carlotta Sacerdote, Oxana Gavrilyuk, Steinar Kristiansen & 17 others Laudina Rodríguez, Catalina Bonet, José María Huerta, Aurelio Barricarte, Maria José Sánchez, Miren Dorronsoro, Karin Jirström, Martin Almquist, Annika Idahl, H. Bas Bueno-De-Mesquita, Marie Braem, Charlotte Onland-Moret, Konstantinos K. Tsilidis, Naomi E. Allen, Veronika Fedirko, E. Riboli, Rudolf Kaaks

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.08-3.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.26-4.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.07-4.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype.

Original languageEnglish
Pages (from-to)2204-2210
Number of pages7
JournalInternational Journal of Cancer
Volume130
Issue number9
DOIs
Publication statusPublished - May 1 2012

Fingerprint

Cohort Studies
Smoking
Neoplasms
Confidence Intervals
Tobacco Products
Confounding Factors (Epidemiology)
Ovarian epithelial cancer
Proportional Hazards Models
Ovarian Neoplasms
Multicenter Studies
Life Style
Odds Ratio
Prospective Studies
Health

Keywords

  • EPIC cohort
  • mucinous
  • ovarian cancer
  • serous
  • smoking

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gram, I. T., Lukanova, A., Brill, I., Braaten, T., Lund, E., Lundin, E., ... Kaaks, R. (2012). Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. International Journal of Cancer, 130(9), 2204-2210. https://doi.org/10.1002/ijc.26235

Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. / Gram, Inger T.; Lukanova, Annekatrin; Brill, Ilene; Braaten, Tonje; Lund, Eiliv; Lundin, Eva; Overvad, Kim; Tjã̧nneland, Anne; Clavel-Chapelon, Francoise; Chabbert-Buffet, Nathalie; Bamia, Christina; Trichopoulou, Antonia; Zylis, Dimosthenis; Masala, Giovanna; Berrino, Franco; Galasso, Rocco; Tumino, Rosario; Sacerdote, Carlotta; Gavrilyuk, Oxana; Kristiansen, Steinar; Rodríguez, Laudina; Bonet, Catalina; Huerta, José María; Barricarte, Aurelio; Sánchez, Maria José; Dorronsoro, Miren; Jirström, Karin; Almquist, Martin; Idahl, Annika; Bueno-De-Mesquita, H. Bas; Braem, Marie; Onland-Moret, Charlotte; Tsilidis, Konstantinos K.; Allen, Naomi E.; Fedirko, Veronika; Riboli, E.; Kaaks, Rudolf.

In: International Journal of Cancer, Vol. 130, No. 9, 01.05.2012, p. 2204-2210.

Research output: Contribution to journalArticle

Gram, IT, Lukanova, A, Brill, I, Braaten, T, Lund, E, Lundin, E, Overvad, K, Tjã̧nneland, A, Clavel-Chapelon, F, Chabbert-Buffet, N, Bamia, C, Trichopoulou, A, Zylis, D, Masala, G, Berrino, F, Galasso, R, Tumino, R, Sacerdote, C, Gavrilyuk, O, Kristiansen, S, Rodríguez, L, Bonet, C, Huerta, JM, Barricarte, A, Sánchez, MJ, Dorronsoro, M, Jirström, K, Almquist, M, Idahl, A, Bueno-De-Mesquita, HB, Braem, M, Onland-Moret, C, Tsilidis, KK, Allen, NE, Fedirko, V, Riboli, E & Kaaks, R 2012, 'Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study', International Journal of Cancer, vol. 130, no. 9, pp. 2204-2210. https://doi.org/10.1002/ijc.26235
Gram, Inger T. ; Lukanova, Annekatrin ; Brill, Ilene ; Braaten, Tonje ; Lund, Eiliv ; Lundin, Eva ; Overvad, Kim ; Tjã̧nneland, Anne ; Clavel-Chapelon, Francoise ; Chabbert-Buffet, Nathalie ; Bamia, Christina ; Trichopoulou, Antonia ; Zylis, Dimosthenis ; Masala, Giovanna ; Berrino, Franco ; Galasso, Rocco ; Tumino, Rosario ; Sacerdote, Carlotta ; Gavrilyuk, Oxana ; Kristiansen, Steinar ; Rodríguez, Laudina ; Bonet, Catalina ; Huerta, José María ; Barricarte, Aurelio ; Sánchez, Maria José ; Dorronsoro, Miren ; Jirström, Karin ; Almquist, Martin ; Idahl, Annika ; Bueno-De-Mesquita, H. Bas ; Braem, Marie ; Onland-Moret, Charlotte ; Tsilidis, Konstantinos K. ; Allen, Naomi E. ; Fedirko, Veronika ; Riboli, E. ; Kaaks, Rudolf. / Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study. In: International Journal of Cancer. 2012 ; Vol. 130, No. 9. pp. 2204-2210.
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abstract = "New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95{\%} confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95{\%} CI 1.08-3.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95{\%} CI 1.26-4.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95{\%} CI 1.07-4.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype.",
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AU - Lund, Eiliv

AU - Lundin, Eva

AU - Overvad, Kim

AU - Tjã̧nneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Chabbert-Buffet, Nathalie

AU - Bamia, Christina

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Masala, Giovanna

AU - Berrino, Franco

AU - Galasso, Rocco

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Gavrilyuk, Oxana

AU - Kristiansen, Steinar

AU - Rodríguez, Laudina

AU - Bonet, Catalina

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Sánchez, Maria José

AU - Dorronsoro, Miren

AU - Jirström, Karin

AU - Almquist, Martin

AU - Idahl, Annika

AU - Bueno-De-Mesquita, H. Bas

AU - Braem, Marie

AU - Onland-Moret, Charlotte

AU - Tsilidis, Konstantinos K.

AU - Allen, Naomi E.

AU - Fedirko, Veronika

AU - Riboli, E.

AU - Kaaks, Rudolf

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