Cigarette smoking and risk of hodgkin lymphoma and its subtypes: A pooled analysis from the international lymphoma epidemiology consortium (InterLymph)

M. Kamper-Jørgensen, K. Rostgaard, S. L. Glaser, S. H. Zahm, W. Cozen, K. E. Smedby, S. Sanjosé, E. T. Chang, T. Zheng, C. La Vecchia, D. Serraino, A. Monnereau, E. V. Kane, L. Miligi, P. Vineis, J. J. Spinelli, J. R. McLaughlin, P. Pahwa, J. A. Dosman, M. VornanenL. Foretova, M. Maynadie, A. Staines, N. Becker, A. Nieters, P. Brennan, P. Boffetta, P. Cocco, H. Hjalgrim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.

Original languageEnglish
Article numbermdt218
Pages (from-to)2245-2255
Number of pages11
JournalAnnals of Oncology
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Hodgkin Disease
Lymphoma
Epidemiology
Smoking
Odds Ratio
Confidence Intervals
Human Herpesvirus 4
Sclerosis
Tobacco Products
Case-Control Studies
Histology

Keywords

  • Case-control
  • Cigarette smoking
  • Epidemiology
  • Epstein-Barr virus
  • Hodgkin lymphoma
  • Individual patient data meta-analysis

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Kamper-Jørgensen, M., Rostgaard, K., Glaser, S. L., Zahm, S. H., Cozen, W., Smedby, K. E., ... Hjalgrim, H. (2013). Cigarette smoking and risk of hodgkin lymphoma and its subtypes: A pooled analysis from the international lymphoma epidemiology consortium (InterLymph). Annals of Oncology, 24(9), 2245-2255. [mdt218]. https://doi.org/10.1093/annonc/mdt218

Cigarette smoking and risk of hodgkin lymphoma and its subtypes : A pooled analysis from the international lymphoma epidemiology consortium (InterLymph). / Kamper-Jørgensen, M.; Rostgaard, K.; Glaser, S. L.; Zahm, S. H.; Cozen, W.; Smedby, K. E.; Sanjosé, S.; Chang, E. T.; Zheng, T.; La Vecchia, C.; Serraino, D.; Monnereau, A.; Kane, E. V.; Miligi, L.; Vineis, P.; Spinelli, J. J.; McLaughlin, J. R.; Pahwa, P.; Dosman, J. A.; Vornanen, M.; Foretova, L.; Maynadie, M.; Staines, A.; Becker, N.; Nieters, A.; Brennan, P.; Boffetta, P.; Cocco, P.; Hjalgrim, H.

In: Annals of Oncology, Vol. 24, No. 9, mdt218, 09.2013, p. 2245-2255.

Research output: Contribution to journalArticle

Kamper-Jørgensen, M, Rostgaard, K, Glaser, SL, Zahm, SH, Cozen, W, Smedby, KE, Sanjosé, S, Chang, ET, Zheng, T, La Vecchia, C, Serraino, D, Monnereau, A, Kane, EV, Miligi, L, Vineis, P, Spinelli, JJ, McLaughlin, JR, Pahwa, P, Dosman, JA, Vornanen, M, Foretova, L, Maynadie, M, Staines, A, Becker, N, Nieters, A, Brennan, P, Boffetta, P, Cocco, P & Hjalgrim, H 2013, 'Cigarette smoking and risk of hodgkin lymphoma and its subtypes: A pooled analysis from the international lymphoma epidemiology consortium (InterLymph)', Annals of Oncology, vol. 24, no. 9, mdt218, pp. 2245-2255. https://doi.org/10.1093/annonc/mdt218
Kamper-Jørgensen, M. ; Rostgaard, K. ; Glaser, S. L. ; Zahm, S. H. ; Cozen, W. ; Smedby, K. E. ; Sanjosé, S. ; Chang, E. T. ; Zheng, T. ; La Vecchia, C. ; Serraino, D. ; Monnereau, A. ; Kane, E. V. ; Miligi, L. ; Vineis, P. ; Spinelli, J. J. ; McLaughlin, J. R. ; Pahwa, P. ; Dosman, J. A. ; Vornanen, M. ; Foretova, L. ; Maynadie, M. ; Staines, A. ; Becker, N. ; Nieters, A. ; Brennan, P. ; Boffetta, P. ; Cocco, P. ; Hjalgrim, H. / Cigarette smoking and risk of hodgkin lymphoma and its subtypes : A pooled analysis from the international lymphoma epidemiology consortium (InterLymph). In: Annals of Oncology. 2013 ; Vol. 24, No. 9. pp. 2245-2255.
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abstract = "Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5{\%} of cases and 57.4{\%} of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95{\%} confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95{\%} CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95{\%} CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95{\%} CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95{\%} CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.",
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T1 - Cigarette smoking and risk of hodgkin lymphoma and its subtypes

T2 - A pooled analysis from the international lymphoma epidemiology consortium (InterLymph)

AU - Kamper-Jørgensen, M.

AU - Rostgaard, K.

AU - Glaser, S. L.

AU - Zahm, S. H.

AU - Cozen, W.

AU - Smedby, K. E.

AU - Sanjosé, S.

AU - Chang, E. T.

AU - Zheng, T.

AU - La Vecchia, C.

AU - Serraino, D.

AU - Monnereau, A.

AU - Kane, E. V.

AU - Miligi, L.

AU - Vineis, P.

AU - Spinelli, J. J.

AU - McLaughlin, J. R.

AU - Pahwa, P.

AU - Dosman, J. A.

AU - Vornanen, M.

AU - Foretova, L.

AU - Maynadie, M.

AU - Staines, A.

AU - Becker, N.

AU - Nieters, A.

AU - Brennan, P.

AU - Boffetta, P.

AU - Cocco, P.

AU - Hjalgrim, H.

PY - 2013/9

Y1 - 2013/9

N2 - Background: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. Patients and methods: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. Results: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. Conclusion: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified.

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