Cigarette smoking and ulcerative colitis. A case control study

D. Lorusso, S. Leo, G. Misciagna, V. Guerra

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In order to examine the relationship between cigarette smoking and ulcerative colitis (UC), we carried out a case-control study of smoking habits in 84 patients with UC and in two different types of controls: 84 taken from a hospital population and 84 from the general population, matched to the cases for age, sex, school education and social class. Non-smokers were found to have a greater UC risk than smokers in both internal controls (Odds ratio = 4.6, 95% CL = 1.8-11.7) and external controls (OR = 10, 95% CL = 3.6-26.9). There was a larger number of ex-smokers among patients with UC than among the controls. Evaluations at the time of disease onset also demonstrated that ex-smokers had a greater relative risk. Furthermore, 84% of the ex-smoker patients had stopped smoking before the onset of symptoms. Conditional multiple logistic regression with the introduction of alcohol (wine) and coffee as additional variable factors to age, sex, education and social class confirmed the independent protective effect of smoking on UC (OR for internal controls = 4.2, 95% CL = 1.7-10.2, OR for external controls = 5.7, 95% CL = 2.3-14.1). There results indicate that non-smokers and especially ex-smokers of cigarettes have a great risk of UC, and thus confirm the results of other studies.

Original languageEnglish
Pages (from-to)202-204
Number of pages3
JournalHepato-Gastroenterology
Volume36
Issue number4
Publication statusPublished - 1989

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Ulcerative Colitis
Case-Control Studies
Smoking
Sex Education
Social Class
Age Factors
Coffee
Wine
Tobacco Products
Population
Habits
Logistic Models
Odds Ratio
Alcohols

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cigarette smoking and ulcerative colitis. A case control study. / Lorusso, D.; Leo, S.; Misciagna, G.; Guerra, V.

In: Hepato-Gastroenterology, Vol. 36, No. 4, 1989, p. 202-204.

Research output: Contribution to journalArticle

Lorusso, D, Leo, S, Misciagna, G & Guerra, V 1989, 'Cigarette smoking and ulcerative colitis. A case control study', Hepato-Gastroenterology, vol. 36, no. 4, pp. 202-204.
Lorusso, D. ; Leo, S. ; Misciagna, G. ; Guerra, V. / Cigarette smoking and ulcerative colitis. A case control study. In: Hepato-Gastroenterology. 1989 ; Vol. 36, No. 4. pp. 202-204.
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