Abstract
We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
| Original language | English |
|---|---|
| Pages (from-to) | 61-67 |
| Number of pages | 7 |
| Journal | Journal of Investigative Dermatology |
| Volume | 125 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2005 |
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Keywords
- Body mass index
- Case-control study
- Family history
- Life events
- Psoriasis
- Risk factors
- Smoking habits
ASJC Scopus subject areas
- Dermatology
Cite this
Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis : Results from an Italian case-control study. / Naldi, Luigi; Chatenoud, Liliane; Linder, Dennis; Fortina, Anna Belloni; Peserico, Andrea; Virgili, Anna Rosa; Bruni, Pier Luigi; Ingordo, Vito; Lo Scocco, Giovanni; Solaroli, Carmen; Schena, Donatella; Barba, Annalisa; Di Landro, Anna; Pezzarossa, Enrico; Arcangeli, Fabio; Gianni, Claudia; Betti, Roberto; Carli, Paolo; Farris, Alessandro; Barabino, Gian Franco; La Vecchia, Carlo.
In: Journal of Investigative Dermatology, Vol. 125, No. 1, 07.2005, p. 61-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis
T2 - Results from an Italian case-control study
AU - Naldi, Luigi
AU - Chatenoud, Liliane
AU - Linder, Dennis
AU - Fortina, Anna Belloni
AU - Peserico, Andrea
AU - Virgili, Anna Rosa
AU - Bruni, Pier Luigi
AU - Ingordo, Vito
AU - Lo Scocco, Giovanni
AU - Solaroli, Carmen
AU - Schena, Donatella
AU - Barba, Annalisa
AU - Di Landro, Anna
AU - Pezzarossa, Enrico
AU - Arcangeli, Fabio
AU - Gianni, Claudia
AU - Betti, Roberto
AU - Carli, Paolo
AU - Farris, Alessandro
AU - Barabino, Gian Franco
AU - La Vecchia, Carlo
PY - 2005/7
Y1 - 2005/7
N2 - We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
AB - We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.
KW - Body mass index
KW - Case-control study
KW - Family history
KW - Life events
KW - Psoriasis
KW - Risk factors
KW - Smoking habits
UR - http://www.scopus.com/inward/record.url?scp=22144490239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22144490239&partnerID=8YFLogxK
U2 - 10.1111/j.0022-202X.2005.23681.x
DO - 10.1111/j.0022-202X.2005.23681.x
M3 - Article
C2 - 15982303
AN - SCOPUS:22144490239
VL - 125
SP - 61
EP - 67
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 1
ER -