Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study

Luigi Naldi, Liliane Chatenoud, Dennis Linder, Anna Belloni Fortina, Andrea Peserico, Anna Rosa Virgili, Pier Luigi Bruni, Vito Ingordo, Giovanni Lo Scocco, Carmen Solaroli, Donatella Schena, Annalisa Barba, Anna Di Landro, Enrico Pezzarossa, Fabio Arcangeli, Claudia Gianni, Roberto Betti, Paolo Carli, Alessandro Farris, Gian Franco BarabinoCarlo La Vecchia

Research output: Contribution to journalArticle

Abstract

We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalJournal of Investigative Dermatology
Volume125
Issue number1
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Psoriasis
Tobacco Products
Case-Control Studies
Body Mass Index
Smoking
Skin
Habits
Skin Manifestations
Skin Diseases

Keywords

  • Body mass index
  • Case-control study
  • Family history
  • Life events
  • Psoriasis
  • Risk factors
  • Smoking habits

ASJC Scopus subject areas

  • Dermatology

Cite this

Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis : Results from an Italian case-control study. / Naldi, Luigi; Chatenoud, Liliane; Linder, Dennis; Fortina, Anna Belloni; Peserico, Andrea; Virgili, Anna Rosa; Bruni, Pier Luigi; Ingordo, Vito; Lo Scocco, Giovanni; Solaroli, Carmen; Schena, Donatella; Barba, Annalisa; Di Landro, Anna; Pezzarossa, Enrico; Arcangeli, Fabio; Gianni, Claudia; Betti, Roberto; Carli, Paolo; Farris, Alessandro; Barabino, Gian Franco; La Vecchia, Carlo.

In: Journal of Investigative Dermatology, Vol. 125, No. 1, 07.2005, p. 61-67.

Research output: Contribution to journalArticle

Naldi, L, Chatenoud, L, Linder, D, Fortina, AB, Peserico, A, Virgili, AR, Bruni, PL, Ingordo, V, Lo Scocco, G, Solaroli, C, Schena, D, Barba, A, Di Landro, A, Pezzarossa, E, Arcangeli, F, Gianni, C, Betti, R, Carli, P, Farris, A, Barabino, GF & La Vecchia, C 2005, 'Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study', Journal of Investigative Dermatology, vol. 125, no. 1, pp. 61-67. https://doi.org/10.1111/j.0022-202X.2005.23681.x
Naldi, Luigi ; Chatenoud, Liliane ; Linder, Dennis ; Fortina, Anna Belloni ; Peserico, Andrea ; Virgili, Anna Rosa ; Bruni, Pier Luigi ; Ingordo, Vito ; Lo Scocco, Giovanni ; Solaroli, Carmen ; Schena, Donatella ; Barba, Annalisa ; Di Landro, Anna ; Pezzarossa, Enrico ; Arcangeli, Fabio ; Gianni, Claudia ; Betti, Roberto ; Carli, Paolo ; Farris, Alessandro ; Barabino, Gian Franco ; La Vecchia, Carlo. / Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis : Results from an Italian case-control study. In: Journal of Investigative Dermatology. 2005 ; Vol. 125, No. 1. pp. 61-67.
@article{be0dabce365046aa8925ae59a9e3d5d2,
title = "Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study",
abstract = "We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.",
keywords = "Body mass index, Case-control study, Family history, Life events, Psoriasis, Risk factors, Smoking habits",
author = "Luigi Naldi and Liliane Chatenoud and Dennis Linder and Fortina, {Anna Belloni} and Andrea Peserico and Virgili, {Anna Rosa} and Bruni, {Pier Luigi} and Vito Ingordo and {Lo Scocco}, Giovanni and Carmen Solaroli and Donatella Schena and Annalisa Barba and {Di Landro}, Anna and Enrico Pezzarossa and Fabio Arcangeli and Claudia Gianni and Roberto Betti and Paolo Carli and Alessandro Farris and Barabino, {Gian Franco} and {La Vecchia}, Carlo",
year = "2005",
month = "7",
doi = "10.1111/j.0022-202X.2005.23681.x",
language = "English",
volume = "125",
pages = "61--67",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis

T2 - Results from an Italian case-control study

AU - Naldi, Luigi

AU - Chatenoud, Liliane

AU - Linder, Dennis

AU - Fortina, Anna Belloni

AU - Peserico, Andrea

AU - Virgili, Anna Rosa

AU - Bruni, Pier Luigi

AU - Ingordo, Vito

AU - Lo Scocco, Giovanni

AU - Solaroli, Carmen

AU - Schena, Donatella

AU - Barba, Annalisa

AU - Di Landro, Anna

AU - Pezzarossa, Enrico

AU - Arcangeli, Fabio

AU - Gianni, Claudia

AU - Betti, Roberto

AU - Carli, Paolo

AU - Farris, Alessandro

AU - Barabino, Gian Franco

AU - La Vecchia, Carlo

PY - 2005/7

Y1 - 2005/7

N2 - We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.

AB - We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n = 560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n = 690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR = 5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR = 1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI ≥ 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values ≥ 115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction.

KW - Body mass index

KW - Case-control study

KW - Family history

KW - Life events

KW - Psoriasis

KW - Risk factors

KW - Smoking habits

UR - http://www.scopus.com/inward/record.url?scp=22144490239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144490239&partnerID=8YFLogxK

U2 - 10.1111/j.0022-202X.2005.23681.x

DO - 10.1111/j.0022-202X.2005.23681.x

M3 - Article

C2 - 15982303

AN - SCOPUS:22144490239

VL - 125

SP - 61

EP - 67

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 1

ER -