Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

Maria Fusaro, Maurizio Gallieni, Andrea Aghi, Giorgio Iervasi, Maria A. Rizzo, Andrea Stucchi, Marianna Noale, Giovanni Tripepi, Thomas Nickolas, Nicola Veronese, Fabrizio Fabris, Sandro Giannini, Lorenzo Calò, Antonio Piccoli, Maria C. Mereu, Laura Cosmai, Alberto Ferraro, Fiorenza Magonara, Michela Spinello, Stefania SellaMario Plebani

Research output: Contribution to journalArticle

Abstract

Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalCurrent Vascular Pharmacology
Volume16
Issue number6
DOIs
Publication statusPublished - Jan 1 2018

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Osteocalcin
Renal Dialysis
Smoking
Vitamin K
Vascular Calcification
Protective Agents
Physiologic Calcification
Osteoporosis
Chronic Kidney Failure
Blood Vessels
Spine
Phosphates
Bone and Bones
Health
Population

Keywords

  • BGP
  • Bone
  • Haemodialysis
  • Osteocalcin
  • Smoke
  • Vascular calcification
  • Vertebral fractures

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients. / Fusaro, Maria; Gallieni, Maurizio; Aghi, Andrea; Iervasi, Giorgio; Rizzo, Maria A.; Stucchi, Andrea; Noale, Marianna; Tripepi, Giovanni; Nickolas, Thomas; Veronese, Nicola; Fabris, Fabrizio; Giannini, Sandro; Calò, Lorenzo; Piccoli, Antonio; Mereu, Maria C.; Cosmai, Laura; Ferraro, Alberto; Magonara, Fiorenza; Spinello, Michela; Sella, Stefania; Plebani, Mario.

In: Current Vascular Pharmacology, Vol. 16, No. 6, 01.01.2018, p. 603-609.

Research output: Contribution to journalArticle

Fusaro, M, Gallieni, M, Aghi, A, Iervasi, G, Rizzo, MA, Stucchi, A, Noale, M, Tripepi, G, Nickolas, T, Veronese, N, Fabris, F, Giannini, S, Calò, L, Piccoli, A, Mereu, MC, Cosmai, L, Ferraro, A, Magonara, F, Spinello, M, Sella, S & Plebani, M 2018, 'Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients', Current Vascular Pharmacology, vol. 16, no. 6, pp. 603-609. https://doi.org/10.2174/1570161115666170919182421
Fusaro, Maria ; Gallieni, Maurizio ; Aghi, Andrea ; Iervasi, Giorgio ; Rizzo, Maria A. ; Stucchi, Andrea ; Noale, Marianna ; Tripepi, Giovanni ; Nickolas, Thomas ; Veronese, Nicola ; Fabris, Fabrizio ; Giannini, Sandro ; Calò, Lorenzo ; Piccoli, Antonio ; Mereu, Maria C. ; Cosmai, Laura ; Ferraro, Alberto ; Magonara, Fiorenza ; Spinello, Michela ; Sella, Stefania ; Plebani, Mario. / Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients. In: Current Vascular Pharmacology. 2018 ; Vol. 16, No. 6. pp. 603-609.
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abstract = "Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37{\%} (136) smokers (or ex-smokers) and 63{\%} (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18{\%} (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.",
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T1 - Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

AU - Fusaro, Maria

AU - Gallieni, Maurizio

AU - Aghi, Andrea

AU - Iervasi, Giorgio

AU - Rizzo, Maria A.

AU - Stucchi, Andrea

AU - Noale, Marianna

AU - Tripepi, Giovanni

AU - Nickolas, Thomas

AU - Veronese, Nicola

AU - Fabris, Fabrizio

AU - Giannini, Sandro

AU - Calò, Lorenzo

AU - Piccoli, Antonio

AU - Mereu, Maria C.

AU - Cosmai, Laura

AU - Ferraro, Alberto

AU - Magonara, Fiorenza

AU - Spinello, Michela

AU - Sella, Stefania

AU - Plebani, Mario

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

AB - Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

KW - BGP

KW - Bone

KW - Haemodialysis

KW - Osteocalcin

KW - Smoke

KW - Vascular calcification

KW - Vertebral fractures

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