Cigarette tar yield and risk of upper digestive tract cancers: Case-control studies from Italy and Switzerland

S. Gallus, A. Altieri, C. Bosetti, S. Franceschi, F. Levi, E. Negri, L. Dal Maso, E. Conti, P. Zambon, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

Background: Tobacco smoking is one of the main risk factors for oral, pharyngeal and oesophageal cancers in developed countries. Information on the role of the tar yield of cigarettes in upper digestive tract carcinogenesis is sparse and needs to be updated because the tar yield of cigarettes has steadily decreased over the last few decades. Patients and methods: We analysed two case-control studies, from Italy and Switzerland, conducted between 1992 and 1999, involving 749 cases of oral and pharyngeal cancer and 1770 controls, and 395 cases of squamous-cell oesophageal carcinoma and 1066 matched controls. Odds ratios (ORs) were estimated by unconditional multiple logistic regression models, including terms for age, sex, study centre, education and alcohol consumption. Results: Based on the brand of cigarettes smoked for the longest time, the multivariate ORs for current smokers compared with never smokers were 6.1 for

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalAnnals of Oncology
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

Keywords

  • Case-control studies
  • Oesophageal cancer
  • Oral cancer
  • Risk factor
  • Tar yield
  • Tobacco smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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