Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice

Giamila Fantuzzi, Fabio Benigni, Marina Sironi, Mario Conni, Maria Carelli, Lavinia Cantoni, Leland Shapiro, Charles A. Dinarello, Jean D. Sipe, Pietro Ghezzi

Research output: Contribution to journalArticle

Abstract

Ciliary neurotrophic factor (CNTF) supports the survival of ciliary ganglion neurons and was shown to induce the synthesis of acute-phase proteins and fever. We studied the effect of CNTF, alone or in association with IL-1, on levels of corticosterone (CS), glucose, serum amyloid A (SAA), and IL-6. We also compared the effect of CNTF with that of IL-6, since the gp130 receptor subunit for CNTF is shared with that of IL-6. A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6. Chronic CNTF, but not IL-6, resulted in decreased food intake and body weight up to days 6-7. After this time, body weight and food intake recovered even if CNTF treatment was continued, indicating that a phenomenon of tolerance occurred. Finally, CNTF (unlike IL-1) was not toxic in adrenalectomized mice. Therefore the similarities of CNTF activities with those of other cytokines, particularly IL-6, might go beyond the activation of the same receptor-signal transduction pathway of IL-6.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalCytokine
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 1995

Keywords

  • acute-phase/hypothalamus-pituitary-adrenal axis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Immunology
  • Molecular Biology
  • Biochemistry
  • Endocrinology

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    Fantuzzi, G., Benigni, F., Sironi, M., Conni, M., Carelli, M., Cantoni, L., Shapiro, L., Dinarello, C. A., Sipe, J. D., & Ghezzi, P. (1995). Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice. Cytokine, 7(2), 150-156. https://doi.org/10.1006/cyto.1995.1020