Cinetic study during aminoacid infusion in catabolic patients

G. Lapichino, R. Ciceri, M. Cambisano, R. Cesari, V. Gavazzeni, M. Marengo, E. Quarenghi, G. Veschi

Research output: Contribution to journalArticlepeer-review


We performed a cinetic study during aminoacids infusion in five catabolic patients. Arterial blood samples were obtained at baseline and after 1, 2, 3, 6, 9, 12, 15, 18, 24, 30, 36, 42, 48 hours of TPN. Urines were also collected daily. The patients were severely catabolic and TPN decreased the catabolism. Twenty-four hours were necessary to reach a steady state in the aminoacid level. Comparing the plasmatic aminoacid profile during TPN with normal profile we could estimate the appropriate supply of each single aminoacid. Seven of given aminoacid (Val, Ile, Leu, Thr, Lys, Phe, Met) were administered at a sufficient amount. Pro input was exceeding the metabolic capability. Arg, Ser, Gly and Glu were slowly normalized while His and Ala were not influenced by treatment. The Tyr low plasmatic levels suggest the opportunity of increasing Phe and Tyr inputs. Some not given aminoacids like Cys, Tau, Glu, Asp and Asn could be thought to have a role as sources of aspecific nitrogen.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
Issue number5
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Surgery


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