Circadian aspects of growth hormoneinsulin-like growth factor axis function in patients with lung cancer

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5 Citations (Scopus)

Abstract

Insulin-like growth factor 1 (IGF1) promotes cell cycle progression and inhibition of apoptosis and may have a role in carcinogenesis and cancer promotion. Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function. In 11 healthy male patients (mean age ± standard error [SE], 43.6 ± 1.7), and 9 male patients with nonsmall-cell lung cancer (mean age ± SE, 51.0 ± 2.4), GH, total IGF1, melatonin, and interleukin (IL)-2 serum levels were measured in blood samples collected every 4 hours for 24 hours. A clear circadian rhythm was present for melatonin and GH serum levels in the group of healthy subjects and for melatonin in the group of patients with cancer. The midline estimating statistic of rhythm (MESOR) of GH was higher in patients with lung cancer (P

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalClinical Lung Cancer
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Growth Hormone
Somatomedins
Lung Neoplasms
Intercellular Signaling Peptides and Proteins
Melatonin
Growth
Healthy Volunteers
Circadian Rhythm
Serum
Non-Small Cell Lung Carcinoma
Interleukin-2
Neoplasms
Cell Cycle
Carcinogenesis
Apoptosis
Liver

Keywords

  • Circadian rhythmicity
  • GH
  • IGF1
  • IL-2
  • Lung cancer
  • Melatonin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "Insulin-like growth factor 1 (IGF1) promotes cell cycle progression and inhibition of apoptosis and may have a role in carcinogenesis and cancer promotion. Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function. In 11 healthy male patients (mean age ± standard error [SE], 43.6 ± 1.7), and 9 male patients with nonsmall-cell lung cancer (mean age ± SE, 51.0 ± 2.4), GH, total IGF1, melatonin, and interleukin (IL)-2 serum levels were measured in blood samples collected every 4 hours for 24 hours. A clear circadian rhythm was present for melatonin and GH serum levels in the group of healthy subjects and for melatonin in the group of patients with cancer. The midline estimating statistic of rhythm (MESOR) of GH was higher in patients with lung cancer (P",
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AU - Sothern, Robert B.

AU - Pazienza, Valerio

AU - Piepoli, Ada

AU - Muscarella, Lucia Anna

AU - Giuliani, Francesco

AU - Tarquini, Roberto

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N2 - Insulin-like growth factor 1 (IGF1) promotes cell cycle progression and inhibition of apoptosis and may have a role in carcinogenesis and cancer promotion. Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function. In 11 healthy male patients (mean age ± standard error [SE], 43.6 ± 1.7), and 9 male patients with nonsmall-cell lung cancer (mean age ± SE, 51.0 ± 2.4), GH, total IGF1, melatonin, and interleukin (IL)-2 serum levels were measured in blood samples collected every 4 hours for 24 hours. A clear circadian rhythm was present for melatonin and GH serum levels in the group of healthy subjects and for melatonin in the group of patients with cancer. The midline estimating statistic of rhythm (MESOR) of GH was higher in patients with lung cancer (P

AB - Insulin-like growth factor 1 (IGF1) promotes cell cycle progression and inhibition of apoptosis and may have a role in carcinogenesis and cancer promotion. Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function. In 11 healthy male patients (mean age ± standard error [SE], 43.6 ± 1.7), and 9 male patients with nonsmall-cell lung cancer (mean age ± SE, 51.0 ± 2.4), GH, total IGF1, melatonin, and interleukin (IL)-2 serum levels were measured in blood samples collected every 4 hours for 24 hours. A clear circadian rhythm was present for melatonin and GH serum levels in the group of healthy subjects and for melatonin in the group of patients with cancer. The midline estimating statistic of rhythm (MESOR) of GH was higher in patients with lung cancer (P

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KW - IGF1

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