Circadian aspects of growth hormoneinsulin-like growth factor axis function in patients with lung cancer

Gianluigi Mazzoccoli, Robert B. Sothern, Valerio Pazienza, Ada Piepoli, Lucia Anna Muscarella, Francesco Giuliani, Roberto Tarquini

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor 1 (IGF1) promotes cell cycle progression and inhibition of apoptosis and may have a role in carcinogenesis and cancer promotion. Growth hormone (GH) stimulates IGF1 production in liver and other tissues. The aim of our study was to evaluate differences between healthy subjects and patients with lung cancer in the GH-IGF1 axis function. In 11 healthy male patients (mean age ± standard error [SE], 43.6 ± 1.7), and 9 male patients with nonsmall-cell lung cancer (mean age ± SE, 51.0 ± 2.4), GH, total IGF1, melatonin, and interleukin (IL)-2 serum levels were measured in blood samples collected every 4 hours for 24 hours. A clear circadian rhythm was present for melatonin and GH serum levels in the group of healthy subjects and for melatonin in the group of patients with cancer. The midline estimating statistic of rhythm (MESOR) of GH was higher in patients with lung cancer (P

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalClinical Lung Cancer
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Circadian rhythmicity
  • GH
  • IGF1
  • IL-2
  • Lung cancer
  • Melatonin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pulmonary and Respiratory Medicine

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