Circadian blood pressure profile in patients with active cushing's disease and after long-term cure

F. Pecori Giraldi, P. M. Toja, M. De Martin, A. Maronati, M. Scacchi, S. Omboni, F. Cavagnini, C. Parati

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Hypertension is a major feature of Cushing's disease, with the attendant increase in the rate of cardiovascular events. The circadian blood pressure profile also impacts cardiovascular risk and a few studies have shown that patients with Cushing's syndrome do not present the expected nocturnal blood pressure decrease and, further, that this alteration persists in short-range disease remission. These studies were performed by conventional discontinuous ambulatory pressure monitoring, a technique not devoid of limitations. Aim of our study was the assessment of blood pressure and heart rate profile by beat-to-beat noninvasive monitoring in twelve patients with active Cushing's disease (9 women and 3 men, age 33.3 ± 2.36 years) and the assessment of its possible changes at short- (<1 year) and long-term (2-3 years) follow-up after curative surgery. No nocturnal blood pressure dipping (i.e., decrease by 10% of daytime values) was observed in 50% of patients both during active hypercortisolism and within 1 year from surgery. Recovery of blood pressure dipping profile was detected at long-term follow-up in a minority of patients. Daytime heart rate was higher in patients with active Cushing's disease and decreased over time after cure. In conclusion, patients with Cushing's disease present absent nocturnal blood pressure dipping and abnormal heart rate values which do not resolve after short-term remission of hypercortisolism and show only partial improvement in the long run. These findings identify additional cardiovascular risk factors for patients cured of Cushing's disease.

Original languageEnglish
Pages (from-to)908-914
Number of pages7
JournalHormone and Metabolic Research
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2007

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Pituitary ACTH Hypersecretion
Blood pressure
Blood Pressure
Cushing Syndrome
Heart Rate
Surgery
Monitoring
Ambulatory Monitoring
Recovery
Hypertension
Pressure

Keywords

  • Blood pressure dipping
  • Cardiovascular risk
  • Hypercortisolism
  • Hypertension
  • Treatment

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Circadian blood pressure profile in patients with active cushing's disease and after long-term cure. / Pecori Giraldi, F.; Toja, P. M.; De Martin, M.; Maronati, A.; Scacchi, M.; Omboni, S.; Cavagnini, F.; Parati, C.

In: Hormone and Metabolic Research, Vol. 39, No. 12, 12.2007, p. 908-914.

Research output: Contribution to journalArticle

Pecori Giraldi, F. ; Toja, P. M. ; De Martin, M. ; Maronati, A. ; Scacchi, M. ; Omboni, S. ; Cavagnini, F. ; Parati, C. / Circadian blood pressure profile in patients with active cushing's disease and after long-term cure. In: Hormone and Metabolic Research. 2007 ; Vol. 39, No. 12. pp. 908-914.
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