Circadian hormonal rhythms in two new cases of fatal familial insomnia.

P. Avoni, P. Cortelli, P. Montagna, P. Tinuper, E. Sforza, M. Contin, P. Parchi, G. Pierangeli, P. Maltoni, A. Pavani

Research output: Contribution to journalArticlepeer-review


We used a chronobiological inferential statistical method to investigate circadian rhythms of hypophyseal hormones, cortisol, melatonin and catecholamines in two females of the same family affected by fatal familial insomnia. Case 1 (confirmed at autopsy) presented an absent or progressive loss of circadian rhythms of all hormones. In case 2 there was a loss of GH circadian rhythm and a less significant rhythm for melatonin, catecholamines and gonadotropins. These results confirm the role of the thalamus in regulating hormonal circadian rhythm.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalActa Neurologica
Issue number6
Publication statusPublished - Dec 1991

ASJC Scopus subject areas

  • Clinical Neurology


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