Circadian hormonal rhythms in two new cases of fatal familial insomnia.

P. Avoni; P. Cortelli; P. Montagna; P. Tinuper; E. Sforza; M. Contin; P. Parchi; G. Pierangeli; P. Maltoni; A. Pavani

Circadian hormonal rhythms in two new cases of fatal familial insomnia.

P. Avoni, P. Cortelli, P. Montagna, P. Tinuper, E. Sforza, M. Contin, P. Parchi, G. Pierangeli, P. Maltoni, A. Pavani

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We used a chronobiological inferential statistical method to investigate circadian rhythms of hypophyseal hormones, cortisol, melatonin and catecholamines in two females of the same family affected by fatal familial insomnia. Case 1 (confirmed at autopsy) presented an absent or progressive loss of circadian rhythms of all hormones. In case 2 there was a loss of GH circadian rhythm and a less significant rhythm for melatonin, catecholamines and gonadotropins. These results confirm the role of the thalamus in regulating hormonal circadian rhythm.

Original language	English
Pages (from-to)	574-576
Number of pages	3
Journal	Acta Neurologica
Volume	13
Issue number	6
Publication status	Published - Dec 1991

ASJC Scopus subject areas

Clinical Neurology

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AU - Avoni, P.

AU - Cortelli, P.

AU - Montagna, P.

AU - Tinuper, P.

AU - Sforza, E.

AU - Contin, M.

AU - Parchi, P.

AU - Pierangeli, G.

AU - Maltoni, P.

AU - Pavani, A.

PY - 1991/12

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N2 - We used a chronobiological inferential statistical method to investigate circadian rhythms of hypophyseal hormones, cortisol, melatonin and catecholamines in two females of the same family affected by fatal familial insomnia. Case 1 (confirmed at autopsy) presented an absent or progressive loss of circadian rhythms of all hormones. In case 2 there was a loss of GH circadian rhythm and a less significant rhythm for melatonin, catecholamines and gonadotropins. These results confirm the role of the thalamus in regulating hormonal circadian rhythm.

AB - We used a chronobiological inferential statistical method to investigate circadian rhythms of hypophyseal hormones, cortisol, melatonin and catecholamines in two females of the same family affected by fatal familial insomnia. Case 1 (confirmed at autopsy) presented an absent or progressive loss of circadian rhythms of all hormones. In case 2 there was a loss of GH circadian rhythm and a less significant rhythm for melatonin, catecholamines and gonadotropins. These results confirm the role of the thalamus in regulating hormonal circadian rhythm.

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SN - 0001-6276

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Circadian hormonal rhythms in two new cases of fatal familial insomnia.

Abstract

ASJC Scopus subject areas

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