Circadian intraocular pressure and blood pressure reduction with timolol 0.5% solution and timogel 0.1% in patients with primary open-angle glaucoma

Luciano Quaranta, Andreas Katsanos, Irene Floriani, Ivano Riva, Andrea Russo, Anastasios G P Konstas

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the circadian and blood pressure (BP) reduction obtained with timolol maleate 0.5% solution administered twice daily versus timolol 0.1% in gel-forming carbomer administered in the morning in patients with primary open-angle glaucoma (POAG). Methods: This investigator-masked, crossover study prospectively enrolled naive POAG patients not receiving systemic cardiovascular medications. Following a baseline evaluation, they were randomized to receive a timolol 0.5% solution or timolol 0.1% hydrogel for 2 months and then switched to the alternative medication for a further 2 months. Intraocular pressure (IOP) phasing (sitting Goldmann tonometry at 10 am, 2 pm, 6 pm, and 10 pm and supine Perkins tonometry at 2 am and 6 am) and ambulatory home BP monitoring were measured at baseline and after each treatment period. Results: On the basis of a prospective sample size estimate, 28 patients were analyzed. Mean 24-hour IOP decreased from 23.1 ± 0.7 mm Hg at baseline to 18.9 ± 0.6 mm Hg after timolol 0.5% and 18.9 ± 0.8 mm Hg after timolol 0.1% hydrogel (P

Original languageEnglish
Pages (from-to)1552-1557
Number of pages6
JournalJournal of Clinical Pharmacology
Volume52
Issue number10
DOIs
Publication statusPublished - Oct 2012

Keywords

  • glaucoma
  • primary open-angle glaucoma
  • Timogel
  • Timolol

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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