Circadian pattern of heart rate variability in chronic heart failure patients: Effects of physical training

S. Adamopoulos, P. Ponikowski, E. Cerquetani, M. Piepoli, G. Rosano, P. Sleight, A. J S Coats

Research output: Contribution to journalArticlepeer-review


The effect of physical training on the circadian pattern of heart rate variability (recorded over 24 h in relation to both time and frequency) was assessed in 12 chronic heart failure patients randomized, in a cross-over design, to 8 weeks training or detraining, and compared with 12 age-matched normals. Training improved heart rate variability indices: all R-R interval 5 min standard deviations increased by 17.6%, the root mean square of the differences of successive R-R intervals by 34.9%, the percentage difference between adjacent normal R-R intervals>50 ms by 112.5%, total power by 58.3%, high frequency by 128.5% and low frequency by 65.0%. Compared with controls, circadian variations in autonomic parameters were maintained in chronic heart failure. Training-induced changes were observed at different time intervals throughout the day: the highest values were at 0100 h-0700 h (detraining: low frequency 361±83 ms2, high frequency 126±47 ms2; training: low frequency 535±202 ms2, high frequency 227±115 ms2, P2, high frequency 39±14 ms2; training: low frequency 154±42 ms2, high frequency 133±67 ms2, P

Original languageEnglish
Pages (from-to)1380-1386
Number of pages7
JournalEuropean Heart Journal
Issue number10
Publication statusPublished - 1995


  • 24 h ECG holter monitoring
  • Autonomic nervous system
  • Heart failure
  • Heart rate variability
  • Power spectral analysis
  • Training

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology


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