Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion—Semicurve findings in adult patients

Raffaele Manni, Roberto De Icco, Riccardo Cremascoli, Giulia Ferrera, Francesca Furia, Elena Zambrelli, Maria Paola Canevini, Michele Terzaghi

Research output: Contribution to journalArticle

Abstract

Objective/background It has been debated in the literature whether patients with idiopathic generalized epilepsy (IGE) have a distinctive, evening-oriented chronotype. The few questionnaire-based studies that are available in the literature have conflicting results. The aim of our study was to define chronotype in patients with IGE by determining dim light melatonin onset (DLMO). Patients/methods Twenty adults diagnosed with IGE (grand mal on awakening [GM] in 7 cases and juvenile myoclonic epilepsy in 13 cases) were investigated by means of a face-to-face semistructured sleep interview, Morningness–Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI) questionnaire, and a melatonin salivary test with DLMO determination. Eighteen healthy subjects (HC) and 28 patients affected with cryptogenic focal epilepsy (FE) served as controls. Results The mean MEQ score was significantly lower in patients with IGE than that in patients with FE (49.1 ± 5.9 versus 56.1 ± 8.7 P 

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalEpilepsy and Behavior
Volume61
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Chronotype
  • DLMO
  • Idiopathic generalized epilepsy
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Fingerprint Dive into the research topics of 'Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion—Semicurve findings in adult patients'. Together they form a unique fingerprint.

  • Cite this