Circadian reduction of chromium in the gastric environment

S. De Flora, G. S. Badolati, D. Serra, A. Picciotto, M. R. Magnolia, V. Savarino

Research output: Contribution to journalArticle

Abstract

Samples of gastric juice from variously treated subjects efficiently reduced hexavalent chromium and decreased its mutagenicity. Chromium reduction was due to thermostable components of gastric secretions and was favoured by the acidity of the intragastric environment. The circadian monitoring of pH and of chromium reduction, as assessed by colorimetric analysis at hourly intervals, showed a basal activity (less than 10 μg/ml gastric juice) during the night and interdigestive periods, and peaks (tens of μg/ml) during the 3-4-h periods after each meal. Assays in the Ames reversion test confirmed that the decrease in mutagenicity of sodium dichromate produced by gastric juice was significantly enhanced after meals. This physiological mechanism is expected to provide an important protective barrier against the oral toxicity of this metal, and may explain its lack of oral carcinogenicity.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalMutation Research Letters
Volume192
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • Chromium
  • Circadian reduction
  • Gastric environment

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

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    De Flora, S., Badolati, G. S., Serra, D., Picciotto, A., Magnolia, M. R., & Savarino, V. (1987). Circadian reduction of chromium in the gastric environment. Mutation Research Letters, 192(3), 169-174. https://doi.org/10.1016/0165-7992(87)90051-0