TY - JOUR
T1 - Circadian rhythm of hepatic cytosolic and nuclear estrogen receptors
AU - Eagon, Patricia K.
AU - Dileo, Alfredo
AU - Polimeno, Lorenzo
AU - Francavilla, Antonio
AU - Van Thiel, David H.
AU - Guglielmi, Francesco
AU - Starzl, Thomas E.
PY - 1986
Y1 - 1986
N2 - The distribution of estrogen receptor between the cytosolic and nuclear compartments were evaluated in liver of male rats to determine whether a circadian rhythm exists. Cytosolic receptor reached a maximum level at 400 hours and a minimum at 2000 and 2400 hr. Nuclear receptor reached a maximum level at 800 hr and was lowest at 1600 and 2000 hr. Serum estradiol levels were also highest at 800 hr and lowest at 1600 hr. The variations in cytosolic and nuclear receptors are not reciprocal; in fact, the overall content of receptor in the liver is not constant and also displays a circadian rhythm.
AB - The distribution of estrogen receptor between the cytosolic and nuclear compartments were evaluated in liver of male rats to determine whether a circadian rhythm exists. Cytosolic receptor reached a maximum level at 400 hours and a minimum at 2000 and 2400 hr. Nuclear receptor reached a maximum level at 800 hr and was lowest at 1600 and 2000 hr. Serum estradiol levels were also highest at 800 hr and lowest at 1600 hr. The variations in cytosolic and nuclear receptors are not reciprocal; in fact, the overall content of receptor in the liver is not constant and also displays a circadian rhythm.
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U2 - 10.3109/07420528609079538
DO - 10.3109/07420528609079538
M3 - Article
C2 - 3677204
AN - SCOPUS:0022830861
VL - 3
SP - 207
EP - 211
JO - Annual Review of Chronopharmacology
JF - Annual Review of Chronopharmacology
SN - 0742-0528
IS - 4
ER -