Circadian rhythm of hepatic cytosolic and nuclear estrogen receptors

Patricia K. Eagon, Alfredo Dileo, Lorenzo Polimeno, Antonio Francavilla, David H. Van Thiel, Francesco Guglielmi, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review


The distribution of estrogen receptor between the cytosolic and nuclear compartments were evaluated in liver of male rats to determine whether a circadian rhythm exists. Cytosolic receptor reached a maximum level at 400 hours and a minimum at 2000 and 2400 hr. Nuclear receptor reached a maximum level at 800 hr and was lowest at 1600 and 2000 hr. Serum estradiol levels were also highest at 800 hr and lowest at 1600 hr. The variations in cytosolic and nuclear receptors are not reciprocal; in fact, the overall content of receptor in the liver is not constant and also displays a circadian rhythm.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalChronobiology International
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Agricultural and Biological Sciences (miscellaneous)


Dive into the research topics of 'Circadian rhythm of hepatic cytosolic and nuclear estrogen receptors'. Together they form a unique fingerprint.

Cite this