Circadian rhythms, adrenergic hormones and trafficking of hematopoietic stem cells

Aldo Giudice, Michele Caraglia, Monica Marra, Maurizio Montella, Nicola Maurea, Alberto Abbruzzese, Claudio Arra

Research output: Contribution to journalArticlepeer-review


Importance of the field: Under homeostasis, small numbers of haematopoietic stem cells (HSCs) are detectable in the bloodstream of mammals, but the mechanisms of their trafficking are unknown. Areas covered in this review: It has been shown that circulating HSCs exhibit marked circadian fluctuations due to standard cycles of 12 h light/12 h darkness. Circadian HSCs oscillations are strongly altered when mice are subjected to continuous light for two weeks or to a jet lag. In addition, circulating HSCs fluctuate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment. Circadian HSC trafficking and expression of CXCL12 are modulated by core genes of the central clock through rhythmic secretion of adrenergic hormones from nerve terminals of the sympathetic nervous system (SNS) in the bone marrow. What the reader will gain: This review summarizes recent findings on the circadian regulation of HSC release in the bone marrow examining the molecular mechanisms through which the central molecular clock regulates CXCL12 in bone marrow stromal cells through rhythmic secretion of adrenergic hormones locally delivered in the bone marrow by nerve terminals from the SNS. Take home message: The circadian HSCs trafficking during steady-state conditions, may promote the maintenance of haematopoiesis through the life of individuals.

Original languageEnglish
Pages (from-to)567-575
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Issue number5
Publication statusPublished - May 2010


  • β-adrenergic receptor
  • Circadian ryhtms
  • CXCL12
  • CXCR4
  • Hematopoiesis

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine


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