Circadian variations of human flexion reflex

Giorgio Sandrini; Enrico Alfonsi; Giorgio Bono; Fabio Facchinetti; Lorenza Montalbetti; Giuseppe Nappi

doi:10.1016/0304-3959(86)90245-9

Circadian variations of human flexion reflex

Giorgio Sandrini, Enrico Alfonsi, Giorgio Bono, Fabio Facchinetti, Lorenza Montalbetti, Giuseppe Nappi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated 8 healthy male volunteers, evaluating RII and RIII thresholds every 6 h starting from noon, for a 24-h period. Both reflex responses exhibited a circadian rhythmicity: the lowest values were found in the early morning (9.1 ± 3.0 and 13.1 ± 4.4 mA, respectively), while the highest values were observed at midnight (13.1 ± 3.5 and 18.5 ± 5.3 mA). Also mean cosinor analysis indicated the existence of a significant rhythm with acrophase at 20:12 for RII and 22:29 for RIII. In 4 subjects, β-endorphin plasma (β-EP) level was tested during the day. No correlation was observed between circadian changes of β-EP and RIII threshold. Other factors are likely to be involved in the circadian variation of nociceptive flexion reflex in man.

Original language	English
Pages (from-to)	403-410
Number of pages	8
Journal	Pain
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0304-3959(86)90245-9
Publication status	Published - 1986

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Neuroscience(all)
Neurology
Pharmacology
Clinical Psychology

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title = "Circadian variations of human flexion reflex",

abstract = "We investigated 8 healthy male volunteers, evaluating RII and RIII thresholds every 6 h starting from noon, for a 24-h period. Both reflex responses exhibited a circadian rhythmicity: the lowest values were found in the early morning (9.1 ± 3.0 and 13.1 ± 4.4 mA, respectively), while the highest values were observed at midnight (13.1 ± 3.5 and 18.5 ± 5.3 mA). Also mean cosinor analysis indicated the existence of a significant rhythm with acrophase at 20:12 for RII and 22:29 for RIII. In 4 subjects, β-endorphin plasma (β-EP) level was tested during the day. No correlation was observed between circadian changes of β-EP and RIII threshold. Other factors are likely to be involved in the circadian variation of nociceptive flexion reflex in man.",

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T1 - Circadian variations of human flexion reflex

AU - Sandrini, Giorgio

AU - Alfonsi, Enrico

AU - Bono, Giorgio

AU - Facchinetti, Fabio

AU - Montalbetti, Lorenza

AU - Nappi, Giuseppe

PY - 1986

Y1 - 1986

N2 - We investigated 8 healthy male volunteers, evaluating RII and RIII thresholds every 6 h starting from noon, for a 24-h period. Both reflex responses exhibited a circadian rhythmicity: the lowest values were found in the early morning (9.1 ± 3.0 and 13.1 ± 4.4 mA, respectively), while the highest values were observed at midnight (13.1 ± 3.5 and 18.5 ± 5.3 mA). Also mean cosinor analysis indicated the existence of a significant rhythm with acrophase at 20:12 for RII and 22:29 for RIII. In 4 subjects, β-endorphin plasma (β-EP) level was tested during the day. No correlation was observed between circadian changes of β-EP and RIII threshold. Other factors are likely to be involved in the circadian variation of nociceptive flexion reflex in man.

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