TY - JOUR
T1 - Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development
AU - Di Agostino, Silvia
AU - Riccioli, Anna
AU - De Cesaris, Paola
AU - Fontemaggi, Giulia
AU - Blandino, Giovanni
AU - Filippini, Antonio
AU - Fazi, Francesco
N1 - Funding Information:
The research leading to these results has received funding from the AIRC IG 2018 – ID. 21406 project, Istituto Pasteur Italia Fondazione Cenci Bolognetti and “Progetti Ateneo” Sapienza University of Rome to FF.
Publisher Copyright:
© Copyright © 2020 Di Agostino, Riccioli, De Cesaris, Fontemaggi, Blandino, Filippini and Fazi.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/27
Y1 - 2020/5/27
N2 - In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors.
AB - In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors.
KW - cancer
KW - circRNA
KW - development
KW - embryogenesis
KW - stemness
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U2 - 10.3389/fcell.2020.00389
DO - 10.3389/fcell.2020.00389
M3 - Review article
AN - SCOPUS:85086152960
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 389
ER -