Circulating adipokines and metabolic setting in differentiated thyroid cancer

Chiara Mele, Maria Teresa Samà, Alessandro Angelo Bisoffi, Marina Caputo, Valentina Bullara, Stefania Mai, Gillian Elisabeth Walker, Flavia Prodam, Paolo Marzullo, Gianluca Aimaretti, Loredana Pagano

Research output: Contribution to journalArticle

Abstract

The associative link relating insulin resistance (IR) and adipokines to the occurrence and phenotype of differentiated thyroid cancer (DTC) is unknown. The aim of this study was to evaluate the relationship between IR and adipokines in DTC p atients, as compared with carriers of benign thyroid diseases (BTD) and healthy cont rols. This observational study enrolled 77 subjects phenotyped as DTC (N = 30), BTD (N = 27) and healthy subjects (N = 20). Each subject underwent preoperative analysis of anthropometric parameters, thyroid function and autoimmunity, insulin resistance (HOMA-IR) and levels of unacylated (UAG) and acylated ghrelin (AG), obestatin, leptin and adiponectin. Multivariate regression models were used to test the predictive role of metabolic corre lates on thyroid phenotypes and DTC extension. The three groups showed similar age, gender distribution, smoking habit, BMI and thyroid parameters. Obestatin was significantly h igher in DTC group compared to BTD (P < 0.05) and control subjects (P < 0.0001). DTC and BTD groups showed higher levels of UAG (P < 0.01) and AG (P < 0.05). Leptin levels were comparable between groups, whereas adiponectin levels were lower in DTC compared t o BTD group (P < 0.0001) and controls (P < 0.01). In parallel, HOMA-IR was higher in DTC than BTD ( P < 0.05) and control group (P < 0.01). Stepwise multivariable regression analysis showed that obestatin and UAG were independent predictors of DTC (P = 0.01 for both). In an analysis restricted to the DTC group, obestatin levels were associated with the abs ence of lymph node metastases (P < 0.05). Our results highlight a potential association between metabolic setting, circulating adipokines and thyroid cancer phenotype.

Original languageEnglish
Pages (from-to)997-1006
Number of pages10
JournalEndocrine Connections
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 2019

Fingerprint

Adipokines
Thyroid Neoplasms
Ghrelin
Thyroid Diseases
Insulin Resistance
Thyroid Gland
Adiponectin
Leptin
Phenotype
Age Distribution
Autoimmunity
Habits
Observational Studies
Healthy Volunteers

Keywords

  • Adipokines
  • Histological phenotype
  • Insulin resistance
  • Thyroid cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Mele, C., Samà, M. T., Bisoffi, A. A., Caputo, M., Bullara, V., Mai, S., ... Pagano, L. (2019). Circulating adipokines and metabolic setting in differentiated thyroid cancer. Endocrine Connections, 8(7), 997-1006. https://doi.org/10.1530/EC-19-0262

Circulating adipokines and metabolic setting in differentiated thyroid cancer. / Mele, Chiara; Samà, Maria Teresa; Bisoffi, Alessandro Angelo; Caputo, Marina; Bullara, Valentina; Mai, Stefania; Walker, Gillian Elisabeth; Prodam, Flavia; Marzullo, Paolo; Aimaretti, Gianluca; Pagano, Loredana.

In: Endocrine Connections, Vol. 8, No. 7, 07.2019, p. 997-1006.

Research output: Contribution to journalArticle

Mele, C, Samà, MT, Bisoffi, AA, Caputo, M, Bullara, V, Mai, S, Walker, GE, Prodam, F, Marzullo, P, Aimaretti, G & Pagano, L 2019, 'Circulating adipokines and metabolic setting in differentiated thyroid cancer', Endocrine Connections, vol. 8, no. 7, pp. 997-1006. https://doi.org/10.1530/EC-19-0262
Mele, Chiara ; Samà, Maria Teresa ; Bisoffi, Alessandro Angelo ; Caputo, Marina ; Bullara, Valentina ; Mai, Stefania ; Walker, Gillian Elisabeth ; Prodam, Flavia ; Marzullo, Paolo ; Aimaretti, Gianluca ; Pagano, Loredana. / Circulating adipokines and metabolic setting in differentiated thyroid cancer. In: Endocrine Connections. 2019 ; Vol. 8, No. 7. pp. 997-1006.
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