Circulating adiponectin levels are paradoxically associated with mortality rate: A systematic review and meta-analysis

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Context: Some studies have surprisingly indicated that serum adiponectin level is positively related to mortality rate, thus casting doubts on its role as a therapeutic target for cardiovascular disease. Objective: To summarize evidence about direction, strength, and modulators of this controversial association. Methods: MEDLINE, Web of Science, CINHAL, Cochrane Library, and Scopus databases were searched from their inception dates through June 2018 for English-language prospective studies reporting the association between adiponectin and all-cause or cardiovascular mortality. Two investigators independently extracted data and assessed study quality using standard criteria following the Preferred Reporting Items for Systematic Reviews and Meta-analyses and The Newcastle-Ottawa Scale. Pooled hazard ratios (HRs) and 95% CIs were derived using fixed- or random-effects models when appropriate, and results were expressed to a 1-SD increment of adiponectin. Results: We identified 55 studies (n = 61,676 subjects) with all-cause mortality data and 28 (n = 43,979 subjects) studies with cardiovascular mortality data. Pooled HRs were 1.24 (1.17-1.31) and 1.28 (1.19-1.37) for all-cause and cardiovascular mortality, respectively. Similar results were obtained for high-molecular-weight adiponectin. When meta-analyses were restricted to studies reporting data on natriuretic peptides, reductions of 43% and 28% on a log scale of these respective associations were observed after adjusting for natriuretic peptides. Conclusions: Our results point strongly to a paradoxical association between high adiponectin levels and increased mortality rate, which is partly modulated by natriuretic peptides.

Original languageEnglish
Pages (from-to)1357-1368
Number of pages12
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number5
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Adiponectin
Meta-Analysis
Natriuretic Peptides
Mortality
Association reactions
Hazards
Modulators
Casting
MEDLINE
Libraries
Molecular weight
Research Design
Cardiovascular Diseases
Language
Molecular Weight
Research Personnel
Databases
Prospective Studies
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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title = "Circulating adiponectin levels are paradoxically associated with mortality rate: A systematic review and meta-analysis",
abstract = "Context: Some studies have surprisingly indicated that serum adiponectin level is positively related to mortality rate, thus casting doubts on its role as a therapeutic target for cardiovascular disease. Objective: To summarize evidence about direction, strength, and modulators of this controversial association. Methods: MEDLINE, Web of Science, CINHAL, Cochrane Library, and Scopus databases were searched from their inception dates through June 2018 for English-language prospective studies reporting the association between adiponectin and all-cause or cardiovascular mortality. Two investigators independently extracted data and assessed study quality using standard criteria following the Preferred Reporting Items for Systematic Reviews and Meta-analyses and The Newcastle-Ottawa Scale. Pooled hazard ratios (HRs) and 95{\%} CIs were derived using fixed- or random-effects models when appropriate, and results were expressed to a 1-SD increment of adiponectin. Results: We identified 55 studies (n = 61,676 subjects) with all-cause mortality data and 28 (n = 43,979 subjects) studies with cardiovascular mortality data. Pooled HRs were 1.24 (1.17-1.31) and 1.28 (1.19-1.37) for all-cause and cardiovascular mortality, respectively. Similar results were obtained for high-molecular-weight adiponectin. When meta-analyses were restricted to studies reporting data on natriuretic peptides, reductions of 43{\%} and 28{\%} on a log scale of these respective associations were observed after adjusting for natriuretic peptides. Conclusions: Our results point strongly to a paradoxical association between high adiponectin levels and increased mortality rate, which is partly modulated by natriuretic peptides.",
author = "Scarale, {Maria Giovanna} and Andrea Fontana and Vincenzo Trischitta and Massimiliano Copetti and Claudia Menzaghi",
year = "2019",
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volume = "104",
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T1 - Circulating adiponectin levels are paradoxically associated with mortality rate

T2 - A systematic review and meta-analysis

AU - Scarale, Maria Giovanna

AU - Fontana, Andrea

AU - Trischitta, Vincenzo

AU - Copetti, Massimiliano

AU - Menzaghi, Claudia

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Context: Some studies have surprisingly indicated that serum adiponectin level is positively related to mortality rate, thus casting doubts on its role as a therapeutic target for cardiovascular disease. Objective: To summarize evidence about direction, strength, and modulators of this controversial association. Methods: MEDLINE, Web of Science, CINHAL, Cochrane Library, and Scopus databases were searched from their inception dates through June 2018 for English-language prospective studies reporting the association between adiponectin and all-cause or cardiovascular mortality. Two investigators independently extracted data and assessed study quality using standard criteria following the Preferred Reporting Items for Systematic Reviews and Meta-analyses and The Newcastle-Ottawa Scale. Pooled hazard ratios (HRs) and 95% CIs were derived using fixed- or random-effects models when appropriate, and results were expressed to a 1-SD increment of adiponectin. Results: We identified 55 studies (n = 61,676 subjects) with all-cause mortality data and 28 (n = 43,979 subjects) studies with cardiovascular mortality data. Pooled HRs were 1.24 (1.17-1.31) and 1.28 (1.19-1.37) for all-cause and cardiovascular mortality, respectively. Similar results were obtained for high-molecular-weight adiponectin. When meta-analyses were restricted to studies reporting data on natriuretic peptides, reductions of 43% and 28% on a log scale of these respective associations were observed after adjusting for natriuretic peptides. Conclusions: Our results point strongly to a paradoxical association between high adiponectin levels and increased mortality rate, which is partly modulated by natriuretic peptides.

AB - Context: Some studies have surprisingly indicated that serum adiponectin level is positively related to mortality rate, thus casting doubts on its role as a therapeutic target for cardiovascular disease. Objective: To summarize evidence about direction, strength, and modulators of this controversial association. Methods: MEDLINE, Web of Science, CINHAL, Cochrane Library, and Scopus databases were searched from their inception dates through June 2018 for English-language prospective studies reporting the association between adiponectin and all-cause or cardiovascular mortality. Two investigators independently extracted data and assessed study quality using standard criteria following the Preferred Reporting Items for Systematic Reviews and Meta-analyses and The Newcastle-Ottawa Scale. Pooled hazard ratios (HRs) and 95% CIs were derived using fixed- or random-effects models when appropriate, and results were expressed to a 1-SD increment of adiponectin. Results: We identified 55 studies (n = 61,676 subjects) with all-cause mortality data and 28 (n = 43,979 subjects) studies with cardiovascular mortality data. Pooled HRs were 1.24 (1.17-1.31) and 1.28 (1.19-1.37) for all-cause and cardiovascular mortality, respectively. Similar results were obtained for high-molecular-weight adiponectin. When meta-analyses were restricted to studies reporting data on natriuretic peptides, reductions of 43% and 28% on a log scale of these respective associations were observed after adjusting for natriuretic peptides. Conclusions: Our results point strongly to a paradoxical association between high adiponectin levels and increased mortality rate, which is partly modulated by natriuretic peptides.

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