Circulating aldosterone and natriuretic peptides in the general community relationship to cardiorenal and metabolic disease

Alessia Buglioni, Valentina Cannone, Alessandro Cataliotti, S. Jeson Sangaralingham, Denise M. Heublein, Christopher G. Scott, Kent R. Bailey, Richard J. Rodeheffer, Paolo Dessì-Fulgheri, Riccardo Sarzani, John C. Burnett

Research output: Contribution to journalArticle

Abstract

We sought to investigate the role of aldosterone as a mediator of disease and its relationship with the counterregulatory natriuretic peptide (NP) system. We measured plasma aldosterone (n=1674; aged≥45 years old) in a random sample of the general population from Olmsted County, MN. In a multivariate logistic regression model, aldosterone analyzed as a continuous variable was associated with hypertension (odds ratio [OR]=1.75; 95% confidence interval [CI]=1.57-1.96; P

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalHypertension
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 20 2015

Keywords

  • Aldosterone
  • Biomarkers
  • Chronic Kidney Disease
  • Hypertension
  • Natriuretic Peptides
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Buglioni, A., Cannone, V., Cataliotti, A., Jeson Sangaralingham, S., Heublein, D. M., Scott, C. G., Bailey, K. R., Rodeheffer, R. J., Dessì-Fulgheri, P., Sarzani, R., & Burnett, J. C. (2015). Circulating aldosterone and natriuretic peptides in the general community relationship to cardiorenal and metabolic disease. Hypertension, 65(1), 45-53. https://doi.org/10.1161/HYPERTENSIONAHA.114.03936