Circulating C-reactive protein concentrations and risks of colon and rectal cancer: A nested case-control study within the European prospective investigation into cancer and nutrition

Krasimira Aleksandrova, Mazda Jenab, Heiner Boeing, Eugene Jansen, H. Bas Bueno-De-Mesquita, Sabina Rinaldi, Elio Riboli, Kim Overvad, Christina C. Dahm, Anja Olsen, Anne Tjønneland, Marie Christine Boutron-Ruault, Franoise Clavel-Chapelon, Sophie Morois, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Vineis, Salvatore Panico, Rudolf KaaksSabine Rohrmann, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Fränzel J B Van Duijnhoven, Anke M. Leufkens, Petra H. Peeters, Laudina Rodríguez, Catalina Bonet, María José Sánchez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte, Richard Palmqvist, Göran Hallmans, Kay Tee Khaw, Nicholas Wareham, Naomi E. Allen, Elizabeth Spencer, Dora Romaguera, Teresa Norat, Tobias Pischon

Research output: Contribution to journalArticle

Abstract

The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of ≥3.0 mg/L versus

Original languageEnglish
Pages (from-to)407-418
Number of pages12
JournalAmerican Journal of Epidemiology
Volume172
Issue number4
DOIs
Publication statusPublished - Aug 15 2010

Keywords

  • abdominal
  • C-reactive protein
  • colorectal neoplasms
  • hyperglycemia
  • hyperinsulinism
  • hyperlipidemias
  • inflammation
  • obesity

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

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  • Cite this

    Aleksandrova, K., Jenab, M., Boeing, H., Jansen, E., Bueno-De-Mesquita, H. B., Rinaldi, S., Riboli, E., Overvad, K., Dahm, C. C., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Morois, S., Palli, D., Krogh, V., Tumino, R., Vineis, P., Panico, S., ... Pischon, T. (2010). Circulating C-reactive protein concentrations and risks of colon and rectal cancer: A nested case-control study within the European prospective investigation into cancer and nutrition. American Journal of Epidemiology, 172(4), 407-418. https://doi.org/10.1093/aje/kwq135