Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis

Domenico Plantone, Alessandro Marti, Giovanni Frisullo, Raffaele Iorio, Valentina Damato, Viviana Nociti, Agata Katia Patanella, Assunta Bianco, Massimiliano Mirabella, Anna Paola Batocchi

Research output: Contribution to journalArticle

Abstract

In this study we evaluated the percentages of CD3-CD56bright, CD3-CD56dim, CD3-CD56brightperforin+ and CD3-CD56dimperforin+ Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects.Both PPMS patients and SPMS patients showed increased percentages of circulating CD3-CD56dimperforin+ NK cells than healthy subjects. The increased percentage of CD3-CD56dim NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalJournal of Neuroimmunology
Volume265
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2013

Keywords

  • Cytotoxicity
  • Natural Killer cells
  • Progressive multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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    Plantone, D., Marti, A., Frisullo, G., Iorio, R., Damato, V., Nociti, V., Patanella, A. K., Bianco, A., Mirabella, M., & Batocchi, A. P. (2013). Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis. Journal of Neuroimmunology, 265(1-2), 124-127. https://doi.org/10.1016/j.jneuroim.2013.10.004