Circulating CD8 +CD56 -perforin + T cells are increased in multiple sclerosis patients

Frisullo Giovanni, Plantone Domenico, Marti Alessandro, Iorio Raffaele, Nociti Viviana, Patanella Agata Katia, Batocchi Anna Paola

Research output: Contribution to journalArticlepeer-review


Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8 +CD56 -perforin + T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8 +CD56 - T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8 +CD56 -perforin + T cells than patients with EDSS +CD56 -perforin + T cells that may play a role in the development of disability.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalJournal of Neuroimmunology
Publication statusPublished - Dec 15 2011


  • CD8 T cells
  • Disability progression
  • Multiple sclerosis
  • Perforin

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology


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