Circulating chromogranin A and its fragments as diagnostic and prognostic disease markers

Angelo Corti, Fabrizio Marcucci, Tiziana Bachetti

Research output: Contribution to journalReview article

Abstract

Chromogranin A (CgA), a secretory protein released in the blood by neuroendocrine cells and neurons, is the precursor of various bioactive fragments involved in the regulation of the cardiovascular system, metabolism, innate immunity, angiogenesis, and tissue repair. After the original demonstration that circulating CgA can serve as a biomarker for a wide range of neuroendocrine tumors, several studies have shown that increased levels of CgA can be present also in the blood of patients with cardiovascular, gastrointestinal, and inflammatory diseases with, in certain cases, important diagnostic and prognostic implications. Considering the high structural and functional heterogeneity of the CgA system, comprising precursor and fragments, it is not surprising that the different immunoassays used in these studies led, in some cases, to discrepant results. Here, we review these notions and we discuss the importance of measuring total-CgA, full-length CgA, specific fragments, and their relative levels for a more thorough assessment of the pathophysiological function and diagnostic/prognostic value of the CgA system.

Original languageEnglish
Pages (from-to)199-210
Number of pages12
JournalPflugers Archiv European Journal of Physiology
Volume470
Issue number1
DOIs
Publication statusPublished - Jan 2018

    Fingerprint

Cite this