Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: Results from the European prospective investigation into cancer and nutrition study

Mattias Johansson, Paul N. Appleby, Naomi E. Allen, Ruth C. Travis, Andrew W. Roddam, Lars Egevad, Mazda Jenab, Sabina Rinaldi, Lambertus A. Kiemeney, H. Bas Bueno-de-Mesquita, Stein Emil Vollset, Per M. Ueland, Maria José Sánchez, J. Ramón Quirós, Carlos A. González, Nerea Larrañaga, María Dolores Chirlaque, Eva Ardanaz, Sabina Sieri, Domenico PalliPaolo Vineis, Rosario Tumino, Jakob Linseisen, Rudolf Kaaks, Heiner Boeing, Tobias Pischon, Theodora Psaltopoulou, Antonia Trichopoulou, Dimitrios Trichopoulos, Kay Tee Khaw, Sheila Bingham, Göran Hallmans, Elio Riboli, Pär Stattin, Timothy J. Key

Research output: Contribution to journalArticle

Abstract

Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B 12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2008

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Johansson, M., Appleby, P. N., Allen, N. E., Travis, R. C., Roddam, A. W., Egevad, L., Jenab, M., Rinaldi, S., Kiemeney, L. A., Bueno-de-Mesquita, H. B., Vollset, S. E., Ueland, P. M., Sánchez, M. J., Quirós, J. R., González, C. A., Larrañaga, N., Chirlaque, M. D., Ardanaz, E., Sieri, S., ... Key, T. J. (2008). Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: Results from the European prospective investigation into cancer and nutrition study. Cancer Epidemiology Biomarkers and Prevention, 17(2), 279-285. https://doi.org/10.1158/1055-9965.EPI-07-0657