Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: Results from the European prospective investigation into cancer and nutrition study

Mattias Johansson, Paul N. Appleby, Naomi E. Allen, Ruth C. Travis, Andrew W. Roddam, Lars Egevad, Mazda Jenab, Sabina Rinaldi, Lambertus A. Kiemeney, H. Bas Bueno-de-Mesquita, Stein Emil Vollset, Per M. Ueland, Maria José Sánchez, J. Ramón Quirós, Carlos A. González, Nerea Larrañaga, María Dolores Chirlaque, Eva Ardanaz, Sabina Sieri, Domenico PalliPaolo Vineis, Rosario Tumino, Jakob Linseisen, Rudolf Kaaks, Heiner Boeing, Tobias Pischon, Theodora Psaltopoulou, Antonia Trichopoulou, Dimitrios Trichopoulos, Kay Tee Khaw, Sheila Bingham, Göran Hallmans, Elio Riboli, Pär Stattin, Timothy J. Key

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Abstract

Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B 12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2008

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Vitamin B 12
Folic Acid
Prostatic Neoplasms
Neoplasms
Confidence Intervals
Logistic Models
Carbon
Prospective Studies

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk : Results from the European prospective investigation into cancer and nutrition study. / Johansson, Mattias; Appleby, Paul N.; Allen, Naomi E.; Travis, Ruth C.; Roddam, Andrew W.; Egevad, Lars; Jenab, Mazda; Rinaldi, Sabina; Kiemeney, Lambertus A.; Bueno-de-Mesquita, H. Bas; Vollset, Stein Emil; Ueland, Per M.; Sánchez, Maria José; Quirós, J. Ramón; González, Carlos A.; Larrañaga, Nerea; Chirlaque, María Dolores; Ardanaz, Eva; Sieri, Sabina; Palli, Domenico; Vineis, Paolo; Tumino, Rosario; Linseisen, Jakob; Kaaks, Rudolf; Boeing, Heiner; Pischon, Tobias; Psaltopoulou, Theodora; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Khaw, Kay Tee; Bingham, Sheila; Hallmans, Göran; Riboli, Elio; Stattin, Pär; Key, Timothy J.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 2, 01.02.2008, p. 279-285.

Research output: Contribution to journalArticle

Johansson, M, Appleby, PN, Allen, NE, Travis, RC, Roddam, AW, Egevad, L, Jenab, M, Rinaldi, S, Kiemeney, LA, Bueno-de-Mesquita, HB, Vollset, SE, Ueland, PM, Sánchez, MJ, Quirós, JR, González, CA, Larrañaga, N, Chirlaque, MD, Ardanaz, E, Sieri, S, Palli, D, Vineis, P, Tumino, R, Linseisen, J, Kaaks, R, Boeing, H, Pischon, T, Psaltopoulou, T, Trichopoulou, A, Trichopoulos, D, Khaw, KT, Bingham, S, Hallmans, G, Riboli, E, Stattin, P & Key, TJ 2008, 'Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: Results from the European prospective investigation into cancer and nutrition study', Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 2, pp. 279-285. https://doi.org/10.1158/1055-9965.EPI-07-0657
Johansson, Mattias ; Appleby, Paul N. ; Allen, Naomi E. ; Travis, Ruth C. ; Roddam, Andrew W. ; Egevad, Lars ; Jenab, Mazda ; Rinaldi, Sabina ; Kiemeney, Lambertus A. ; Bueno-de-Mesquita, H. Bas ; Vollset, Stein Emil ; Ueland, Per M. ; Sánchez, Maria José ; Quirós, J. Ramón ; González, Carlos A. ; Larrañaga, Nerea ; Chirlaque, María Dolores ; Ardanaz, Eva ; Sieri, Sabina ; Palli, Domenico ; Vineis, Paolo ; Tumino, Rosario ; Linseisen, Jakob ; Kaaks, Rudolf ; Boeing, Heiner ; Pischon, Tobias ; Psaltopoulou, Theodora ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Khaw, Kay Tee ; Bingham, Sheila ; Hallmans, Göran ; Riboli, Elio ; Stattin, Pär ; Key, Timothy J. / Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk : Results from the European prospective investigation into cancer and nutrition study. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; Vol. 17, No. 2. pp. 279-285.
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title = "Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: Results from the European prospective investigation into cancer and nutrition study",
abstract = "Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B 12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95{\%} confidence interval (95{\%} CI), 0.92-1.16] and 1.12 (95{\%} CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95{\%} CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.",
author = "Mattias Johansson and Appleby, {Paul N.} and Allen, {Naomi E.} and Travis, {Ruth C.} and Roddam, {Andrew W.} and Lars Egevad and Mazda Jenab and Sabina Rinaldi and Kiemeney, {Lambertus A.} and Bueno-de-Mesquita, {H. Bas} and Vollset, {Stein Emil} and Ueland, {Per M.} and S{\'a}nchez, {Maria Jos{\'e}} and Quir{\'o}s, {J. Ram{\'o}n} and Gonz{\'a}lez, {Carlos A.} and Nerea Larra{\~n}aga and Chirlaque, {Mar{\'i}a Dolores} and Eva Ardanaz and Sabina Sieri and Domenico Palli and Paolo Vineis and Rosario Tumino and Jakob Linseisen and Rudolf Kaaks and Heiner Boeing and Tobias Pischon and Theodora Psaltopoulou and Antonia Trichopoulou and Dimitrios Trichopoulos and Khaw, {Kay Tee} and Sheila Bingham and G{\"o}ran Hallmans and Elio Riboli and P{\"a}r Stattin and Key, {Timothy J.}",
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TY - JOUR

T1 - Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk

T2 - Results from the European prospective investigation into cancer and nutrition study

AU - Johansson, Mattias

AU - Appleby, Paul N.

AU - Allen, Naomi E.

AU - Travis, Ruth C.

AU - Roddam, Andrew W.

AU - Egevad, Lars

AU - Jenab, Mazda

AU - Rinaldi, Sabina

AU - Kiemeney, Lambertus A.

AU - Bueno-de-Mesquita, H. Bas

AU - Vollset, Stein Emil

AU - Ueland, Per M.

AU - Sánchez, Maria José

AU - Quirós, J. Ramón

AU - González, Carlos A.

AU - Larrañaga, Nerea

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Sieri, Sabina

AU - Palli, Domenico

AU - Vineis, Paolo

AU - Tumino, Rosario

AU - Linseisen, Jakob

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Pischon, Tobias

AU - Psaltopoulou, Theodora

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Khaw, Kay Tee

AU - Bingham, Sheila

AU - Hallmans, Göran

AU - Riboli, Elio

AU - Stattin, Pär

AU - Key, Timothy J.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B 12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.

AB - Background: Determinants of one-carbon metabolism, such as folate and vitamin B12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B 12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (Ptrend = 0.62) or vitamin B12 (Ptrend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, Ptrend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B12. Elevated concentrations of vitamin B12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.

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U2 - 10.1158/1055-9965.EPI-07-0657

DO - 10.1158/1055-9965.EPI-07-0657

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